GATA transcription factors integrate Wnt signalling during heart development

Boni A. Afouda, Jennifer Martin, Fei Liu, Aldo Ciau-Uitz, Roger Patient, Stefan Hoppler

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Cardiogenesis is inhibited by canonical Wnt/beta-catenin signalling and stimulated by non-canonical Wnt11/JNK signalling, but how these two signalling pathways crosstalk is currently unknown. Here, we show that Wnt/beta-catenin signalling restricts cardiogenesis via inhibition of GATA gene expression, as experimentally reinstating GATA function overrides beta-catenin-mediated inhibition and restores cardiogenesis. Furthermore, we show that GATA transcription factors in turn directly regulate Wnt11 gene expression, and that Wnt11 is required to a significant degree for mediating the cardiogenesis-promoting function of GATA transcription factors. These results demonstrate that GATA factors occupy a central position between canonical and non-canonical Wnt signalling in regulating heart muscle formation.

Original languageEnglish
Pages (from-to)3185-3190
Number of pages6
JournalDevelopment
Volume135
Issue number19
DOIs
Publication statusPublished - 1 Oct 2008

Keywords

  • cardiomyogenesis
  • GATA
  • heart
  • Wnt
  • Xenopus
  • gene-expression
  • cardiovascular differentiation
  • ventral morphogenesis
  • cardiac development
  • xenopus embryos
  • tube formation
  • cardiogenesis
  • zebrafish
  • cardiomycocytes
  • induction

Cite this

Afouda, B. A., Martin, J., Liu, F., Ciau-Uitz, A., Patient, R., & Hoppler, S. (2008). GATA transcription factors integrate Wnt signalling during heart development. Development, 135(19), 3185-3190. https://doi.org/10.1242/dev.026443

GATA transcription factors integrate Wnt signalling during heart development. / Afouda, Boni A.; Martin, Jennifer; Liu, Fei; Ciau-Uitz, Aldo; Patient, Roger; Hoppler, Stefan.

In: Development, Vol. 135, No. 19, 01.10.2008, p. 3185-3190.

Research output: Contribution to journalArticle

Afouda, BA, Martin, J, Liu, F, Ciau-Uitz, A, Patient, R & Hoppler, S 2008, 'GATA transcription factors integrate Wnt signalling during heart development' Development, vol. 135, no. 19, pp. 3185-3190. https://doi.org/10.1242/dev.026443
Afouda, Boni A. ; Martin, Jennifer ; Liu, Fei ; Ciau-Uitz, Aldo ; Patient, Roger ; Hoppler, Stefan. / GATA transcription factors integrate Wnt signalling during heart development. In: Development. 2008 ; Vol. 135, No. 19. pp. 3185-3190.
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