GATA transcription factors integrate Wnt signalling during heart development

Boni A. Afouda, Jennifer Martin, Fei Liu, Aldo Ciau-Uitz, Roger Patient, Stefan Hoppler

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Cardiogenesis is inhibited by canonical Wnt/beta-catenin signalling and stimulated by non-canonical Wnt11/JNK signalling, but how these two signalling pathways crosstalk is currently unknown. Here, we show that Wnt/beta-catenin signalling restricts cardiogenesis via inhibition of GATA gene expression, as experimentally reinstating GATA function overrides beta-catenin-mediated inhibition and restores cardiogenesis. Furthermore, we show that GATA transcription factors in turn directly regulate Wnt11 gene expression, and that Wnt11 is required to a significant degree for mediating the cardiogenesis-promoting function of GATA transcription factors. These results demonstrate that GATA factors occupy a central position between canonical and non-canonical Wnt signalling in regulating heart muscle formation.

Original languageEnglish
Pages (from-to)3185-3190
Number of pages6
JournalDevelopment
Volume135
Issue number19
DOIs
Publication statusPublished - 1 Oct 2008

Keywords

  • cardiomyogenesis
  • GATA
  • heart
  • Wnt
  • Xenopus
  • gene-expression
  • cardiovascular differentiation
  • ventral morphogenesis
  • cardiac development
  • xenopus embryos
  • tube formation
  • cardiogenesis
  • zebrafish
  • cardiomycocytes
  • induction

Fingerprint

Dive into the research topics of 'GATA transcription factors integrate Wnt signalling during heart development'. Together they form a unique fingerprint.

Cite this