Gender difference in determinants of short-term survival of patients with acute myocardial infarction in Isfahan, Iran

Abdollah Mohammadian Hafshejani, Nizal Sarrafzadegan, Hamid Reza Baradaran Attar Moghaddam, Shidokht Hosseini, Mohsen Asadi Lari

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Compared to men, women suffer from acute myocardial infarction (AMI) at higher age. In addition, hypertension, dyslipidemia, diabetes mellitus, and in-hospital mortality are more frequent in women. This study aimed to determine gender-based differences in predictive factors of short-term survival in patients with acute myocardial infarction. Methods: In a cohort study based on hospital records during 1999-2008, all patients with AMI admitted to all public and private hospitals in Isfahan and Najaf Abad (center of Iran) were investigated. To determine predictive factors of short-term (28-day) survival, univariate and multivariate Cox regression analyses were used. Survival rate of patients was calculated using Kaplan--Meier and log rank tests. Findings: Overall, 12815 patients with AMI were included (72.6% male). The adjusted relative risk (RR) of death increased with age. In patients over 80 years of age, RR was 12.7 [95% confidence interval (CI): 5.1-31.3] in men and 8.8 (95% CI: 1.2-63.1) in women. In both genders, RR of anterior wall infarction was greater than inferior wall infarction [3.0 (95% CI: 1.8-5.1) vs. 1.7 (95% CI: 1.0-3.0) in men and 2.2 (95% CI: 1.2-4.0) vs. 1.6 (95% CI: 0.8-2.9) in women]. While survival rate increased in both genders during the study period, this improvement was more apparent in women. Conclusion: Increasing trend of survival rate following an AMI in both genders warrants continuous medical care and public health promotion activities. Physicians will therefore be encouraged to provide more efficient care for patients who are at higher risk of mortality.

Original languageEnglish
JournalJournal of Isfahan Medical School
Volume30
Issue number209
Publication statusPublished - 1 Jan 2012

Fingerprint

Iran
Myocardial Infarction
Confidence Intervals
Survival
Survival Rate
Infarction
Private Hospitals
Hospital Records
Public Hospitals
Dyslipidemias
Hospital Mortality
Health Promotion
Patient Care
Diabetes Mellitus
Cohort Studies
Public Health
Regression Analysis
Hypertension
Physicians
Mortality

Keywords

  • Acute myocardial infarction
  • Cox regression
  • Gender-based differences
  • Iran
  • Short-term survival

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gender difference in determinants of short-term survival of patients with acute myocardial infarction in Isfahan, Iran. / Mohammadian Hafshejani, Abdollah; Sarrafzadegan, Nizal; Baradaran Attar Moghaddam, Hamid Reza; Hosseini, Shidokht; Asadi Lari, Mohsen.

In: Journal of Isfahan Medical School, Vol. 30, No. 209, 01.01.2012.

Research output: Contribution to journalArticle

Mohammadian Hafshejani, Abdollah ; Sarrafzadegan, Nizal ; Baradaran Attar Moghaddam, Hamid Reza ; Hosseini, Shidokht ; Asadi Lari, Mohsen. / Gender difference in determinants of short-term survival of patients with acute myocardial infarction in Isfahan, Iran. In: Journal of Isfahan Medical School. 2012 ; Vol. 30, No. 209.
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abstract = "Background: Compared to men, women suffer from acute myocardial infarction (AMI) at higher age. In addition, hypertension, dyslipidemia, diabetes mellitus, and in-hospital mortality are more frequent in women. This study aimed to determine gender-based differences in predictive factors of short-term survival in patients with acute myocardial infarction. Methods: In a cohort study based on hospital records during 1999-2008, all patients with AMI admitted to all public and private hospitals in Isfahan and Najaf Abad (center of Iran) were investigated. To determine predictive factors of short-term (28-day) survival, univariate and multivariate Cox regression analyses were used. Survival rate of patients was calculated using Kaplan--Meier and log rank tests. Findings: Overall, 12815 patients with AMI were included (72.6{\%} male). The adjusted relative risk (RR) of death increased with age. In patients over 80 years of age, RR was 12.7 [95{\%} confidence interval (CI): 5.1-31.3] in men and 8.8 (95{\%} CI: 1.2-63.1) in women. In both genders, RR of anterior wall infarction was greater than inferior wall infarction [3.0 (95{\%} CI: 1.8-5.1) vs. 1.7 (95{\%} CI: 1.0-3.0) in men and 2.2 (95{\%} CI: 1.2-4.0) vs. 1.6 (95{\%} CI: 0.8-2.9) in women]. While survival rate increased in both genders during the study period, this improvement was more apparent in women. Conclusion: Increasing trend of survival rate following an AMI in both genders warrants continuous medical care and public health promotion activities. Physicians will therefore be encouraged to provide more efficient care for patients who are at higher risk of mortality.",
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T1 - Gender difference in determinants of short-term survival of patients with acute myocardial infarction in Isfahan, Iran

AU - Mohammadian Hafshejani, Abdollah

AU - Sarrafzadegan, Nizal

AU - Baradaran Attar Moghaddam, Hamid Reza

AU - Hosseini, Shidokht

AU - Asadi Lari, Mohsen

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Background: Compared to men, women suffer from acute myocardial infarction (AMI) at higher age. In addition, hypertension, dyslipidemia, diabetes mellitus, and in-hospital mortality are more frequent in women. This study aimed to determine gender-based differences in predictive factors of short-term survival in patients with acute myocardial infarction. Methods: In a cohort study based on hospital records during 1999-2008, all patients with AMI admitted to all public and private hospitals in Isfahan and Najaf Abad (center of Iran) were investigated. To determine predictive factors of short-term (28-day) survival, univariate and multivariate Cox regression analyses were used. Survival rate of patients was calculated using Kaplan--Meier and log rank tests. Findings: Overall, 12815 patients with AMI were included (72.6% male). The adjusted relative risk (RR) of death increased with age. In patients over 80 years of age, RR was 12.7 [95% confidence interval (CI): 5.1-31.3] in men and 8.8 (95% CI: 1.2-63.1) in women. In both genders, RR of anterior wall infarction was greater than inferior wall infarction [3.0 (95% CI: 1.8-5.1) vs. 1.7 (95% CI: 1.0-3.0) in men and 2.2 (95% CI: 1.2-4.0) vs. 1.6 (95% CI: 0.8-2.9) in women]. While survival rate increased in both genders during the study period, this improvement was more apparent in women. Conclusion: Increasing trend of survival rate following an AMI in both genders warrants continuous medical care and public health promotion activities. Physicians will therefore be encouraged to provide more efficient care for patients who are at higher risk of mortality.

AB - Background: Compared to men, women suffer from acute myocardial infarction (AMI) at higher age. In addition, hypertension, dyslipidemia, diabetes mellitus, and in-hospital mortality are more frequent in women. This study aimed to determine gender-based differences in predictive factors of short-term survival in patients with acute myocardial infarction. Methods: In a cohort study based on hospital records during 1999-2008, all patients with AMI admitted to all public and private hospitals in Isfahan and Najaf Abad (center of Iran) were investigated. To determine predictive factors of short-term (28-day) survival, univariate and multivariate Cox regression analyses were used. Survival rate of patients was calculated using Kaplan--Meier and log rank tests. Findings: Overall, 12815 patients with AMI were included (72.6% male). The adjusted relative risk (RR) of death increased with age. In patients over 80 years of age, RR was 12.7 [95% confidence interval (CI): 5.1-31.3] in men and 8.8 (95% CI: 1.2-63.1) in women. In both genders, RR of anterior wall infarction was greater than inferior wall infarction [3.0 (95% CI: 1.8-5.1) vs. 1.7 (95% CI: 1.0-3.0) in men and 2.2 (95% CI: 1.2-4.0) vs. 1.6 (95% CI: 0.8-2.9) in women]. While survival rate increased in both genders during the study period, this improvement was more apparent in women. Conclusion: Increasing trend of survival rate following an AMI in both genders warrants continuous medical care and public health promotion activities. Physicians will therefore be encouraged to provide more efficient care for patients who are at higher risk of mortality.

KW - Acute myocardial infarction

KW - Cox regression

KW - Gender-based differences

KW - Iran

KW - Short-term survival

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JO - Journal of Isfahan Medical School

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