Generality and specificity in cognitive aging: a volumetric brain analysis

Roger T Staff, Alison Dorothy Murray, I. J. Deary, Lawrence Jeffrey Whalley

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Objective: To investigate whether, in old age, brain volume differences are associated with age-related change in general mental ability and/or specific cognitive abilities.

Methods: The authors investigate the association between brain volumes and current cognitive function in a well-characterized sample of healthy old people (aged 79-80) whose intelligence was recorded at age 11. This allowed estimation of intellectual change over the life span.

Results: After accounting for childhood intelligence, associations were found between specific cognitive measures and brain volumes. An association was also found between volumes and the general intelligence factor g. After removing the influence of g from each of the specific cognitive measures, no remaining significant associations were found between brain volumes and the specific part of each test.

Conclusions: Generalized cognitive aging is associated with brain volume differences, but there is no evidence in this sample that specific components of cognitive aging are associated with differences in brain volume. (c) 2005 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)1433-1440
Number of pages7
JournalNeuroimage
Volume30
Issue number4
DOIs
Publication statusPublished - May 2006

Keywords

  • TEMPORAL-LOBE
  • FOLLOW-UP
  • LIFE-SPAN
  • CORTICAL DISCONNECTION
  • INDIVIDUAL-DIFFERENCES
  • MATTER ABNORMALITIES
  • PROCESSING SPEED
  • HEALTHY-ADULTS
  • AGE
  • INTELLIGENCE

Cite this

Generality and specificity in cognitive aging: a volumetric brain analysis. / Staff, Roger T; Murray, Alison Dorothy; Deary, I. J.; Whalley, Lawrence Jeffrey.

In: Neuroimage, Vol. 30, No. 4, 05.2006, p. 1433-1440.

Research output: Contribution to journalArticle

Staff, Roger T ; Murray, Alison Dorothy ; Deary, I. J. ; Whalley, Lawrence Jeffrey. / Generality and specificity in cognitive aging: a volumetric brain analysis. In: Neuroimage. 2006 ; Vol. 30, No. 4. pp. 1433-1440.
@article{9fb309153f5e415da57cfcc29c4dbce1,
title = "Generality and specificity in cognitive aging: a volumetric brain analysis",
abstract = "Objective: To investigate whether, in old age, brain volume differences are associated with age-related change in general mental ability and/or specific cognitive abilities.Methods: The authors investigate the association between brain volumes and current cognitive function in a well-characterized sample of healthy old people (aged 79-80) whose intelligence was recorded at age 11. This allowed estimation of intellectual change over the life span.Results: After accounting for childhood intelligence, associations were found between specific cognitive measures and brain volumes. An association was also found between volumes and the general intelligence factor g. After removing the influence of g from each of the specific cognitive measures, no remaining significant associations were found between brain volumes and the specific part of each test.Conclusions: Generalized cognitive aging is associated with brain volume differences, but there is no evidence in this sample that specific components of cognitive aging are associated with differences in brain volume. (c) 2005 Elsevier Inc. All rights reserved.",
keywords = "TEMPORAL-LOBE, FOLLOW-UP, LIFE-SPAN, CORTICAL DISCONNECTION, INDIVIDUAL-DIFFERENCES, MATTER ABNORMALITIES, PROCESSING SPEED, HEALTHY-ADULTS, AGE, INTELLIGENCE",
author = "Staff, {Roger T} and Murray, {Alison Dorothy} and Deary, {I. J.} and Whalley, {Lawrence Jeffrey}",
year = "2006",
month = "5",
doi = "10.1016/j.neuroimage.2005.11.004",
language = "English",
volume = "30",
pages = "1433--1440",
journal = "Neuroimage",
issn = "1053-8119",
publisher = "Academic Press Inc.",
number = "4",

}

TY - JOUR

T1 - Generality and specificity in cognitive aging: a volumetric brain analysis

AU - Staff, Roger T

AU - Murray, Alison Dorothy

AU - Deary, I. J.

AU - Whalley, Lawrence Jeffrey

PY - 2006/5

Y1 - 2006/5

N2 - Objective: To investigate whether, in old age, brain volume differences are associated with age-related change in general mental ability and/or specific cognitive abilities.Methods: The authors investigate the association between brain volumes and current cognitive function in a well-characterized sample of healthy old people (aged 79-80) whose intelligence was recorded at age 11. This allowed estimation of intellectual change over the life span.Results: After accounting for childhood intelligence, associations were found between specific cognitive measures and brain volumes. An association was also found between volumes and the general intelligence factor g. After removing the influence of g from each of the specific cognitive measures, no remaining significant associations were found between brain volumes and the specific part of each test.Conclusions: Generalized cognitive aging is associated with brain volume differences, but there is no evidence in this sample that specific components of cognitive aging are associated with differences in brain volume. (c) 2005 Elsevier Inc. All rights reserved.

AB - Objective: To investigate whether, in old age, brain volume differences are associated with age-related change in general mental ability and/or specific cognitive abilities.Methods: The authors investigate the association between brain volumes and current cognitive function in a well-characterized sample of healthy old people (aged 79-80) whose intelligence was recorded at age 11. This allowed estimation of intellectual change over the life span.Results: After accounting for childhood intelligence, associations were found between specific cognitive measures and brain volumes. An association was also found between volumes and the general intelligence factor g. After removing the influence of g from each of the specific cognitive measures, no remaining significant associations were found between brain volumes and the specific part of each test.Conclusions: Generalized cognitive aging is associated with brain volume differences, but there is no evidence in this sample that specific components of cognitive aging are associated with differences in brain volume. (c) 2005 Elsevier Inc. All rights reserved.

KW - TEMPORAL-LOBE

KW - FOLLOW-UP

KW - LIFE-SPAN

KW - CORTICAL DISCONNECTION

KW - INDIVIDUAL-DIFFERENCES

KW - MATTER ABNORMALITIES

KW - PROCESSING SPEED

KW - HEALTHY-ADULTS

KW - AGE

KW - INTELLIGENCE

U2 - 10.1016/j.neuroimage.2005.11.004

DO - 10.1016/j.neuroimage.2005.11.004

M3 - Article

VL - 30

SP - 1433

EP - 1440

JO - Neuroimage

JF - Neuroimage

SN - 1053-8119

IS - 4

ER -