Genetic determinants of susceptibility to osteoporosis (Review)

S Ralston

    Research output: Contribution to journalArticle

    41 Citations (Scopus)

    Abstract

    Major advances in our knowledge about the genetic determinants of osteoporosis have been made in recent years. They include the discovery of genes responsible for monogenic bone diseases associated with abnormal bone mass; the identification of quantitative trait loci for bone mass in the general population and in mice; and the characterisation of several candidate genes for osteoporosis. Information from these studies is being used to design new drugs for osteoporosis and to develop genetic markers for fracture risk assessment.

    Original languageEnglish
    Pages (from-to)286-290
    Number of pages4
    JournalCurrent Opinion in Pharmacology
    Volume3
    Issue number3
    DOIs
    Publication statusPublished - 2003

    Keywords

    • BONE-MINERAL DENSITY
    • D-RECEPTOR GENE
    • START CODON POLYMORPHISM
    • QUANTITATIVE TRAIT LOCI
    • SP1 BINDING-SITE
    • FEMORAL-NECK
    • JAPANESE WOMEN
    • PERIMENOPAUSAL WOMEN
    • POSTMENOPAUSAL TWINS
    • SUGGESTIVE LINKAGE

    Cite this

    Genetic determinants of susceptibility to osteoporosis (Review). / Ralston, S.

    In: Current Opinion in Pharmacology, Vol. 3, No. 3, 2003, p. 286-290.

    Research output: Contribution to journalArticle

    @article{1e6daa46da4046cca1913b4211afc074,
    title = "Genetic determinants of susceptibility to osteoporosis (Review)",
    abstract = "Major advances in our knowledge about the genetic determinants of osteoporosis have been made in recent years. They include the discovery of genes responsible for monogenic bone diseases associated with abnormal bone mass; the identification of quantitative trait loci for bone mass in the general population and in mice; and the characterisation of several candidate genes for osteoporosis. Information from these studies is being used to design new drugs for osteoporosis and to develop genetic markers for fracture risk assessment.",
    keywords = "BONE-MINERAL DENSITY, D-RECEPTOR GENE, START CODON POLYMORPHISM, QUANTITATIVE TRAIT LOCI, SP1 BINDING-SITE, FEMORAL-NECK, JAPANESE WOMEN, PERIMENOPAUSAL WOMEN, POSTMENOPAUSAL TWINS, SUGGESTIVE LINKAGE",
    author = "S Ralston",
    year = "2003",
    doi = "10.1016/S1471-4892(03)00033-X",
    language = "English",
    volume = "3",
    pages = "286--290",
    journal = "Current Opinion in Pharmacology",
    issn = "1471-4892",
    publisher = "Elsevier BV",
    number = "3",

    }

    TY - JOUR

    T1 - Genetic determinants of susceptibility to osteoporosis (Review)

    AU - Ralston, S

    PY - 2003

    Y1 - 2003

    N2 - Major advances in our knowledge about the genetic determinants of osteoporosis have been made in recent years. They include the discovery of genes responsible for monogenic bone diseases associated with abnormal bone mass; the identification of quantitative trait loci for bone mass in the general population and in mice; and the characterisation of several candidate genes for osteoporosis. Information from these studies is being used to design new drugs for osteoporosis and to develop genetic markers for fracture risk assessment.

    AB - Major advances in our knowledge about the genetic determinants of osteoporosis have been made in recent years. They include the discovery of genes responsible for monogenic bone diseases associated with abnormal bone mass; the identification of quantitative trait loci for bone mass in the general population and in mice; and the characterisation of several candidate genes for osteoporosis. Information from these studies is being used to design new drugs for osteoporosis and to develop genetic markers for fracture risk assessment.

    KW - BONE-MINERAL DENSITY

    KW - D-RECEPTOR GENE

    KW - START CODON POLYMORPHISM

    KW - QUANTITATIVE TRAIT LOCI

    KW - SP1 BINDING-SITE

    KW - FEMORAL-NECK

    KW - JAPANESE WOMEN

    KW - PERIMENOPAUSAL WOMEN

    KW - POSTMENOPAUSAL TWINS

    KW - SUGGESTIVE LINKAGE

    U2 - 10.1016/S1471-4892(03)00033-X

    DO - 10.1016/S1471-4892(03)00033-X

    M3 - Article

    VL - 3

    SP - 286

    EP - 290

    JO - Current Opinion in Pharmacology

    JF - Current Opinion in Pharmacology

    SN - 1471-4892

    IS - 3

    ER -