Genetic determinants of susceptibility to osteoporosis (Review)

S Ralston

    Research output: Contribution to journalArticle

    41 Citations (Scopus)

    Abstract

    Major advances in our knowledge about the genetic determinants of osteoporosis have been made in recent years. They include the discovery of genes responsible for monogenic bone diseases associated with abnormal bone mass; the identification of quantitative trait loci for bone mass in the general population and in mice; and the characterisation of several candidate genes for osteoporosis. Information from these studies is being used to design new drugs for osteoporosis and to develop genetic markers for fracture risk assessment.

    Original languageEnglish
    Pages (from-to)286-290
    Number of pages4
    JournalCurrent Opinion in Pharmacology
    Volume3
    Issue number3
    DOIs
    Publication statusPublished - 2003

    Keywords

    • BONE-MINERAL DENSITY
    • D-RECEPTOR GENE
    • START CODON POLYMORPHISM
    • QUANTITATIVE TRAIT LOCI
    • SP1 BINDING-SITE
    • FEMORAL-NECK
    • JAPANESE WOMEN
    • PERIMENOPAUSAL WOMEN
    • POSTMENOPAUSAL TWINS
    • SUGGESTIVE LINKAGE

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