Genetic linkage analysis of the antibody responses to myelin basic protein and myelin oligodendrocyte glycoprotein in rats immunized with rat spinal cord homogenate

H. T. Yang; K. Bergsteinsdottir; P. Wernhoff; Christopher Linington; Ulrika Pettersson; R. Holmdahl

doi:10.1016/S0165-5728(01)00320-4

Genetic linkage analysis of the antibody responses to myelin basic protein and myelin oligodendrocyte glycoprotein in rats immunized with rat spinal cord homogenate

H. T. Yang, K. Bergsteinsdottir, P. Wernhoff, Christopher Linington, Ulrika Pettersson, R. Holmdahl

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The genetic control of the antibody response to myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG) was analysed in F1 and F2 crosses of DA and E3 rats, immunized with rat spinal chord homogenate. The DA rats were highly susceptible to encephalomyelitis and made antibody responses to both MBP and MOG, whereas the E3 rats were disease-resistant and responded only to MOG. The anti-MBP response was mainly controlled by the disease-promoting MHC region of the DA strain together with several disease loci outside MHC. ln contrast, the anti-MOG response was associated with loci not related to or actually conferring resistance to disease. (C) 2001 Elsevier Science B.V. All rights reserved.

Original language	English
Pages (from-to)	21-29
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	17
DOIs	https://doi.org/10.1016/S0165-5728(01)00320-4
Publication status	Published - 2001

Keywords

experimental allergic encephalomyelitis autoantibodies
myelin basic protein
myelin oligodendrocyte glycoprotein
genetic analysis
major histocompatibility complex
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
MULTIPLE-SCLEROSIS
B-CELL
DISEASE SUSCEPTIBILITY
RHEUMATOID-ARTHRITIS
DA RATS
EAE
IDENTIFICATION
SPECIFICITY

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10.1016/S0165-5728(01)00320-4

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@article{4b9de81dc6d04484894a324d2cf76283,

title = "Genetic linkage analysis of the antibody responses to myelin basic protein and myelin oligodendrocyte glycoprotein in rats immunized with rat spinal cord homogenate",

abstract = "The genetic control of the antibody response to myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG) was analysed in F1 and F2 crosses of DA and E3 rats, immunized with rat spinal chord homogenate. The DA rats were highly susceptible to encephalomyelitis and made antibody responses to both MBP and MOG, whereas the E3 rats were disease-resistant and responded only to MOG. The anti-MBP response was mainly controlled by the disease-promoting MHC region of the DA strain together with several disease loci outside MHC. ln contrast, the anti-MOG response was associated with loci not related to or actually conferring resistance to disease. (C) 2001 Elsevier Science B.V. All rights reserved.",

keywords = "experimental allergic encephalomyelitis autoantibodies, myelin basic protein, myelin oligodendrocyte glycoprotein, genetic analysis, major histocompatibility complex, EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS, MULTIPLE-SCLEROSIS, B-CELL, DISEASE SUSCEPTIBILITY, RHEUMATOID-ARTHRITIS, DA RATS, EAE, IDENTIFICATION, SPECIFICITY",

author = "Yang, {H. T.} and K. Bergsteinsdottir and P. Wernhoff and Christopher Linington and Ulrika Pettersson and R. Holmdahl",

year = "2001",

doi = "10.1016/S0165-5728(01)00320-4",

language = "English",

volume = "17",

pages = "21--29",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

}

TY - JOUR

T1 - Genetic linkage analysis of the antibody responses to myelin basic protein and myelin oligodendrocyte glycoprotein in rats immunized with rat spinal cord homogenate

AU - Yang, H. T.

AU - Bergsteinsdottir, K.

AU - Wernhoff, P.

AU - Linington, Christopher

AU - Pettersson, Ulrika

AU - Holmdahl, R.

PY - 2001

Y1 - 2001

N2 - The genetic control of the antibody response to myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG) was analysed in F1 and F2 crosses of DA and E3 rats, immunized with rat spinal chord homogenate. The DA rats were highly susceptible to encephalomyelitis and made antibody responses to both MBP and MOG, whereas the E3 rats were disease-resistant and responded only to MOG. The anti-MBP response was mainly controlled by the disease-promoting MHC region of the DA strain together with several disease loci outside MHC. ln contrast, the anti-MOG response was associated with loci not related to or actually conferring resistance to disease. (C) 2001 Elsevier Science B.V. All rights reserved.

AB - The genetic control of the antibody response to myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG) was analysed in F1 and F2 crosses of DA and E3 rats, immunized with rat spinal chord homogenate. The DA rats were highly susceptible to encephalomyelitis and made antibody responses to both MBP and MOG, whereas the E3 rats were disease-resistant and responded only to MOG. The anti-MBP response was mainly controlled by the disease-promoting MHC region of the DA strain together with several disease loci outside MHC. ln contrast, the anti-MOG response was associated with loci not related to or actually conferring resistance to disease. (C) 2001 Elsevier Science B.V. All rights reserved.

KW - experimental allergic encephalomyelitis autoantibodies

KW - myelin basic protein

KW - myelin oligodendrocyte glycoprotein

KW - genetic analysis

KW - major histocompatibility complex

KW - EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

KW - EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS

KW - MULTIPLE-SCLEROSIS

KW - B-CELL

KW - DISEASE SUSCEPTIBILITY

KW - RHEUMATOID-ARTHRITIS

KW - DA RATS

KW - EAE

KW - IDENTIFICATION

KW - SPECIFICITY

U2 - 10.1016/S0165-5728(01)00320-4

DO - 10.1016/S0165-5728(01)00320-4

M3 - Article

SN - 0165-5728

VL - 17

SP - 21

EP - 29

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

Genetic linkage analysis of the antibody responses to myelin basic protein and myelin oligodendrocyte glycoprotein in rats immunized with rat spinal cord homogenate

Abstract

Keywords

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