Genetic linkage analysis of the antibody responses to myelin basic protein and myelin oligodendrocyte glycoprotein in rats immunized with rat spinal cord homogenate

H. T. Yang, K. Bergsteinsdottir, P. Wernhoff, Christopher Linington, Ulrika Pettersson, R. Holmdahl

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    Abstract

    The genetic control of the antibody response to myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG) was analysed in F1 and F2 crosses of DA and E3 rats, immunized with rat spinal chord homogenate. The DA rats were highly susceptible to encephalomyelitis and made antibody responses to both MBP and MOG, whereas the E3 rats were disease-resistant and responded only to MOG. The anti-MBP response was mainly controlled by the disease-promoting MHC region of the DA strain together with several disease loci outside MHC. ln contrast, the anti-MOG response was associated with loci not related to or actually conferring resistance to disease. (C) 2001 Elsevier Science B.V. All rights reserved.

    Original languageEnglish
    Pages (from-to)21-29
    Number of pages8
    JournalJournal of Neuroimmunology
    Volume17
    DOIs
    Publication statusPublished - 2001

    Keywords

    • experimental allergic encephalomyelitis autoantibodies
    • myelin basic protein
    • myelin oligodendrocyte glycoprotein
    • genetic analysis
    • major histocompatibility complex
    • EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
    • EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
    • MULTIPLE-SCLEROSIS
    • B-CELL
    • DISEASE SUSCEPTIBILITY
    • RHEUMATOID-ARTHRITIS
    • DA RATS
    • EAE
    • IDENTIFICATION
    • SPECIFICITY

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