Genetic linkage analysis of the antibody responses to myelin basic protein and myelin oligodendrocyte glycoprotein in rats immunized with rat spinal cord homogenate

H. T. Yang, K. Bergsteinsdottir, P. Wernhoff, Christopher Linington, Ulrika Pettersson, R. Holmdahl

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    The genetic control of the antibody response to myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG) was analysed in F1 and F2 crosses of DA and E3 rats, immunized with rat spinal chord homogenate. The DA rats were highly susceptible to encephalomyelitis and made antibody responses to both MBP and MOG, whereas the E3 rats were disease-resistant and responded only to MOG. The anti-MBP response was mainly controlled by the disease-promoting MHC region of the DA strain together with several disease loci outside MHC. ln contrast, the anti-MOG response was associated with loci not related to or actually conferring resistance to disease. (C) 2001 Elsevier Science B.V. All rights reserved.

    Original languageEnglish
    Pages (from-to)21-29
    Number of pages8
    JournalJournal of Neuroimmunology
    Volume17
    DOIs
    Publication statusPublished - 2001

    Keywords

    • experimental allergic encephalomyelitis autoantibodies
    • myelin basic protein
    • myelin oligodendrocyte glycoprotein
    • genetic analysis
    • major histocompatibility complex
    • EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
    • EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
    • MULTIPLE-SCLEROSIS
    • B-CELL
    • DISEASE SUSCEPTIBILITY
    • RHEUMATOID-ARTHRITIS
    • DA RATS
    • EAE
    • IDENTIFICATION
    • SPECIFICITY

    Cite this

    Genetic linkage analysis of the antibody responses to myelin basic protein and myelin oligodendrocyte glycoprotein in rats immunized with rat spinal cord homogenate. / Yang, H. T.; Bergsteinsdottir, K.; Wernhoff, P.; Linington, Christopher; Pettersson, Ulrika; Holmdahl, R.

    In: Journal of Neuroimmunology, Vol. 17, 2001, p. 21-29.

    Research output: Contribution to journalArticle

    Yang, H. T. ; Bergsteinsdottir, K. ; Wernhoff, P. ; Linington, Christopher ; Pettersson, Ulrika ; Holmdahl, R. / Genetic linkage analysis of the antibody responses to myelin basic protein and myelin oligodendrocyte glycoprotein in rats immunized with rat spinal cord homogenate. In: Journal of Neuroimmunology. 2001 ; Vol. 17. pp. 21-29.
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    abstract = "The genetic control of the antibody response to myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG) was analysed in F1 and F2 crosses of DA and E3 rats, immunized with rat spinal chord homogenate. The DA rats were highly susceptible to encephalomyelitis and made antibody responses to both MBP and MOG, whereas the E3 rats were disease-resistant and responded only to MOG. The anti-MBP response was mainly controlled by the disease-promoting MHC region of the DA strain together with several disease loci outside MHC. ln contrast, the anti-MOG response was associated with loci not related to or actually conferring resistance to disease. (C) 2001 Elsevier Science B.V. All rights reserved.",
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    T1 - Genetic linkage analysis of the antibody responses to myelin basic protein and myelin oligodendrocyte glycoprotein in rats immunized with rat spinal cord homogenate

    AU - Yang, H. T.

    AU - Bergsteinsdottir, K.

    AU - Wernhoff, P.

    AU - Linington, Christopher

    AU - Pettersson, Ulrika

    AU - Holmdahl, R.

    PY - 2001

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    N2 - The genetic control of the antibody response to myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG) was analysed in F1 and F2 crosses of DA and E3 rats, immunized with rat spinal chord homogenate. The DA rats were highly susceptible to encephalomyelitis and made antibody responses to both MBP and MOG, whereas the E3 rats were disease-resistant and responded only to MOG. The anti-MBP response was mainly controlled by the disease-promoting MHC region of the DA strain together with several disease loci outside MHC. ln contrast, the anti-MOG response was associated with loci not related to or actually conferring resistance to disease. (C) 2001 Elsevier Science B.V. All rights reserved.

    AB - The genetic control of the antibody response to myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG) was analysed in F1 and F2 crosses of DA and E3 rats, immunized with rat spinal chord homogenate. The DA rats were highly susceptible to encephalomyelitis and made antibody responses to both MBP and MOG, whereas the E3 rats were disease-resistant and responded only to MOG. The anti-MBP response was mainly controlled by the disease-promoting MHC region of the DA strain together with several disease loci outside MHC. ln contrast, the anti-MOG response was associated with loci not related to or actually conferring resistance to disease. (C) 2001 Elsevier Science B.V. All rights reserved.

    KW - experimental allergic encephalomyelitis autoantibodies

    KW - myelin basic protein

    KW - myelin oligodendrocyte glycoprotein

    KW - genetic analysis

    KW - major histocompatibility complex

    KW - EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

    KW - EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS

    KW - MULTIPLE-SCLEROSIS

    KW - B-CELL

    KW - DISEASE SUSCEPTIBILITY

    KW - RHEUMATOID-ARTHRITIS

    KW - DA RATS

    KW - EAE

    KW - IDENTIFICATION

    KW - SPECIFICITY

    U2 - 10.1016/S0165-5728(01)00320-4

    DO - 10.1016/S0165-5728(01)00320-4

    M3 - Article

    VL - 17

    SP - 21

    EP - 29

    JO - Journal of Neuroimmunology

    JF - Journal of Neuroimmunology

    SN - 0165-5728

    ER -