Genetic polymorphism of HLA DR in a Scottish population of patients with pars planitis

Kathrin Greiner, D. W. Wilson, John Matthew Thomson, D. J. Kilmartin, Stanislaw Urbaniak, John Vincent Forrester

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

PURPOSE. Human leucocyte antigen (HLA) class II influences the immunological susceptibility for a variety of diseases including many types of non-infectious intraocular inflammation. Previous studies on North American patients with pars planitis, a subtype of intermediate uveitis, reported an increased prevalence of HLA DR15 in this population. In contrast, two European studies could not find an association between HLA DR2 or its allelic subtype DR15 and various forms of intermediate uveitis. We therefore investigated the genotype frequency of HLA DR alleles in a Scottish population of patients with typical pars planitis.

METHODS. Twenty patients with pars planitis were identified from the uveitis database of Grampian Universitiy Hospitals. Only patients with bilateral vitritis and snowbanks in at least one eye in the absence of systemic disease were included in the study. Fifteen patients and 34 healthy controls underwent HLA DR genotyping for all DRB genes using PCR sequence specific primers.

RESULTS. HLA DR15 was found in 13% of patients with pars planitis and in 24% of controls. There was no statistically significant difference between these two groups. Furthermore, the frequencies of HLA DR 1, 3-14, and 16 did not differ significantly between patients and controls.

CONCLUSIONS. There appears to be no association between the occurrence of pars planitis and the HLA DR15 or other known HLA DR genotypes in Scottish patients. However, the small sample size limits the power of this study.

Original languageEnglish
Pages (from-to)433-438
Number of pages5
JournalEuropean Journal of Ophthalmology
Volume13
Issue number5
Publication statusPublished - 2003

Keywords

  • Pars planitis
  • uveitis
  • HLA DR
  • genotyping
  • MULTIPLE-SCLEROSIS
  • CLASS-II
  • INTERMEDIATE UVEITIS
  • TRANSGENIC MICE
  • ASSOCIATION
  • DISEASE
  • ANTIGEN
  • POSTERIOR
  • COMPLEX
  • REGION

Cite this

Greiner, K., Wilson, D. W., Thomson, J. M., Kilmartin, D. J., Urbaniak, S., & Forrester, J. V. (2003). Genetic polymorphism of HLA DR in a Scottish population of patients with pars planitis. European Journal of Ophthalmology, 13(5), 433-438.

Genetic polymorphism of HLA DR in a Scottish population of patients with pars planitis. / Greiner, Kathrin; Wilson, D. W.; Thomson, John Matthew; Kilmartin, D. J.; Urbaniak, Stanislaw; Forrester, John Vincent.

In: European Journal of Ophthalmology, Vol. 13, No. 5, 2003, p. 433-438.

Research output: Contribution to journalArticle

Greiner, K, Wilson, DW, Thomson, JM, Kilmartin, DJ, Urbaniak, S & Forrester, JV 2003, 'Genetic polymorphism of HLA DR in a Scottish population of patients with pars planitis', European Journal of Ophthalmology, vol. 13, no. 5, pp. 433-438.
Greiner K, Wilson DW, Thomson JM, Kilmartin DJ, Urbaniak S, Forrester JV. Genetic polymorphism of HLA DR in a Scottish population of patients with pars planitis. European Journal of Ophthalmology. 2003;13(5):433-438.
Greiner, Kathrin ; Wilson, D. W. ; Thomson, John Matthew ; Kilmartin, D. J. ; Urbaniak, Stanislaw ; Forrester, John Vincent. / Genetic polymorphism of HLA DR in a Scottish population of patients with pars planitis. In: European Journal of Ophthalmology. 2003 ; Vol. 13, No. 5. pp. 433-438.
@article{36c86953903f4f428113c758c7d0d970,
title = "Genetic polymorphism of HLA DR in a Scottish population of patients with pars planitis",
abstract = "PURPOSE. Human leucocyte antigen (HLA) class II influences the immunological susceptibility for a variety of diseases including many types of non-infectious intraocular inflammation. Previous studies on North American patients with pars planitis, a subtype of intermediate uveitis, reported an increased prevalence of HLA DR15 in this population. In contrast, two European studies could not find an association between HLA DR2 or its allelic subtype DR15 and various forms of intermediate uveitis. We therefore investigated the genotype frequency of HLA DR alleles in a Scottish population of patients with typical pars planitis.METHODS. Twenty patients with pars planitis were identified from the uveitis database of Grampian Universitiy Hospitals. Only patients with bilateral vitritis and snowbanks in at least one eye in the absence of systemic disease were included in the study. Fifteen patients and 34 healthy controls underwent HLA DR genotyping for all DRB genes using PCR sequence specific primers.RESULTS. HLA DR15 was found in 13{\%} of patients with pars planitis and in 24{\%} of controls. There was no statistically significant difference between these two groups. Furthermore, the frequencies of HLA DR 1, 3-14, and 16 did not differ significantly between patients and controls.CONCLUSIONS. There appears to be no association between the occurrence of pars planitis and the HLA DR15 or other known HLA DR genotypes in Scottish patients. However, the small sample size limits the power of this study.",
keywords = "Pars planitis, uveitis, HLA DR, genotyping, MULTIPLE-SCLEROSIS, CLASS-II, INTERMEDIATE UVEITIS, TRANSGENIC MICE, ASSOCIATION, DISEASE, ANTIGEN, POSTERIOR, COMPLEX, REGION",
author = "Kathrin Greiner and Wilson, {D. W.} and Thomson, {John Matthew} and Kilmartin, {D. J.} and Stanislaw Urbaniak and Forrester, {John Vincent}",
year = "2003",
language = "English",
volume = "13",
pages = "433--438",
journal = "European Journal of Ophthalmology",
issn = "1120-6721",
publisher = "Wichtig Publishing",
number = "5",

}

TY - JOUR

T1 - Genetic polymorphism of HLA DR in a Scottish population of patients with pars planitis

AU - Greiner, Kathrin

AU - Wilson, D. W.

AU - Thomson, John Matthew

AU - Kilmartin, D. J.

AU - Urbaniak, Stanislaw

AU - Forrester, John Vincent

PY - 2003

Y1 - 2003

N2 - PURPOSE. Human leucocyte antigen (HLA) class II influences the immunological susceptibility for a variety of diseases including many types of non-infectious intraocular inflammation. Previous studies on North American patients with pars planitis, a subtype of intermediate uveitis, reported an increased prevalence of HLA DR15 in this population. In contrast, two European studies could not find an association between HLA DR2 or its allelic subtype DR15 and various forms of intermediate uveitis. We therefore investigated the genotype frequency of HLA DR alleles in a Scottish population of patients with typical pars planitis.METHODS. Twenty patients with pars planitis were identified from the uveitis database of Grampian Universitiy Hospitals. Only patients with bilateral vitritis and snowbanks in at least one eye in the absence of systemic disease were included in the study. Fifteen patients and 34 healthy controls underwent HLA DR genotyping for all DRB genes using PCR sequence specific primers.RESULTS. HLA DR15 was found in 13% of patients with pars planitis and in 24% of controls. There was no statistically significant difference between these two groups. Furthermore, the frequencies of HLA DR 1, 3-14, and 16 did not differ significantly between patients and controls.CONCLUSIONS. There appears to be no association between the occurrence of pars planitis and the HLA DR15 or other known HLA DR genotypes in Scottish patients. However, the small sample size limits the power of this study.

AB - PURPOSE. Human leucocyte antigen (HLA) class II influences the immunological susceptibility for a variety of diseases including many types of non-infectious intraocular inflammation. Previous studies on North American patients with pars planitis, a subtype of intermediate uveitis, reported an increased prevalence of HLA DR15 in this population. In contrast, two European studies could not find an association between HLA DR2 or its allelic subtype DR15 and various forms of intermediate uveitis. We therefore investigated the genotype frequency of HLA DR alleles in a Scottish population of patients with typical pars planitis.METHODS. Twenty patients with pars planitis were identified from the uveitis database of Grampian Universitiy Hospitals. Only patients with bilateral vitritis and snowbanks in at least one eye in the absence of systemic disease were included in the study. Fifteen patients and 34 healthy controls underwent HLA DR genotyping for all DRB genes using PCR sequence specific primers.RESULTS. HLA DR15 was found in 13% of patients with pars planitis and in 24% of controls. There was no statistically significant difference between these two groups. Furthermore, the frequencies of HLA DR 1, 3-14, and 16 did not differ significantly between patients and controls.CONCLUSIONS. There appears to be no association between the occurrence of pars planitis and the HLA DR15 or other known HLA DR genotypes in Scottish patients. However, the small sample size limits the power of this study.

KW - Pars planitis

KW - uveitis

KW - HLA DR

KW - genotyping

KW - MULTIPLE-SCLEROSIS

KW - CLASS-II

KW - INTERMEDIATE UVEITIS

KW - TRANSGENIC MICE

KW - ASSOCIATION

KW - DISEASE

KW - ANTIGEN

KW - POSTERIOR

KW - COMPLEX

KW - REGION

M3 - Article

VL - 13

SP - 433

EP - 438

JO - European Journal of Ophthalmology

JF - European Journal of Ophthalmology

SN - 1120-6721

IS - 5

ER -