Genetic risk models in age-related macular degeneration

Felix Grassmann, Iris M. Heid, Bernhard H.F. Weber*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Late-stage age-related macular degeneration (AMD) is a common sightthreatening disease of the central retina affecting approximately 1 in 30 Caucasians. Besides age and smoking, common genetic variants from at least 19 gene loci have reproducibly been associated with AMD likely explaining a large proportion of disease. Based on the current knowledge, several models were calculated to predict disease risk each with its own strength and weakness. Here, we review and compare published genetic risk models for AMD with or without additionally accounting for non-genetic factors.

Original languageEnglish
Pages (from-to)291-300
Number of pages10
JournalAdvances in Experimental Medicine and Biology
Volume801
Early online date25 Mar 2014
DOIs
Publication statusPublished - 2014

Keywords

  • Age-related macular degeneration
  • Cox regression
  • Genetic risk score
  • Logistic regression
  • Susceptibility

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