Genetic variants in t helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population

Rajeev Mahajan, Emad M. El-Omar, Jolanta Lissowska, Paolo Grillo, Charles S. Rabkin, Andrea Baccarelli, Meredith Yeager, Leslie H. Sobin, Witold Zatonski, Stephen J. Channock, Wong-Ho Chow, Lifang Hou

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Host immune responses are known determinants of gastric cancer susceptibility. We previously reported an increased gastric cancer risk associated with common variants of several T helper type 1 (Th1) cytokine genes in a population-based case-control study in Warsaw, Poland. In the present study, we augmented our investigation to include additional Th1 genes as well as key genes in the Th2 and Th3 pathways. Analysis of 378 cases and 435 age- and sex-matched controls revealed associations for polymorphisms in the Th1 IL7R gene and one polymorphism in the Th2 IL5 gene. The odd ratios (ORs) for IL7R rs1494555 were 1.4 [95% confidence interval (CI), 1.0-1.9] for A/G and 1.5 (95% CI, 1.0-2.4) for G/G carriers relative to A/A carriers (P = 0.04). The ORs for IL5 rs2069812 were 0.9 (95% CI, 0.7-1.3) for C/T and 0.6 (95% CI, 0.3-1.0) T/T carriers compared with C/C carriers (P = 0.03). These results suggest that IL5 rs2069812 and IL7R rs1389832, rs1494556 and rs1494555 polymorphisms may contribute to gastric cancer etiology.

Original languageEnglish
Pages (from-to)626-633
Number of pages8
JournalJapanese Journal of Clinical Oncology
Volume38
Issue number9
Early online date7 Aug 2008
DOIs
Publication statusPublished - Sep 2008

Keywords

  • gastric cancer
  • T helper cell pathways
  • polymorphism
  • single nucleotide polymorphisms
  • helicobacter-pylori infection
  • non-Hodgkin-lymphoma
  • CTLA4 gene
  • multiple-sclerosis
  • Korean population
  • stomach-cancer
  • oral tolerance
  • TNF-alpha
  • TGF-beta

Cite this

Mahajan, R., El-Omar, E. M., Lissowska, J., Grillo, P., Rabkin, C. S., Baccarelli, A., Yeager, M., Sobin, L. H., Zatonski, W., Channock, S. J., Chow, W-H., & Hou, L. (2008). Genetic variants in t helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population. Japanese Journal of Clinical Oncology, 38(9), 626-633. https://doi.org/10.1093/jjco/hyn075