Genetic variants linked to coronary artery disease are not associated with carotid artery intima-media thickness or intermediate risk phenotypes

M. S. Cunnington, B. M. Mayosi, D. H. Hall, P. J. Avery, M. Farrall, M. A. Vickers, H. Watkins, B. Keavney

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

It is uncertain whether the novel single nucleotide polymorphisms (SNPs) that have recently been associated with coronary artery disease (CAD) in genome-wide studies also influence carotid atheroma and stroke risk. The mechanisms of their association with CAD are unknown; relationships to other cardiovascular phenotypes may give mechanistic clues. Carotid artery intima-media thickness (CIMT) is a subclinical marker of atherosclerosis associated with stroke. We investigated association of reported CAD risk variants with CIMT, and with other intermediate phenotypes that may implicate causative pathways.

Methods
We studied 1425 members of 248 British Caucasian families ascertained through a hypertensive proband. We genotyped CAD risk SNPs on chromosomes 9 (rs1333049, rs7044859, rs496892, rs7865618), 6 (rs6922269) and 2 (rs2943634) using TaqMan. Merlin software was used for family-based association testing.

Results
No significant association was found between genotype at any SNP and CIMT in 846 individuals with acceptable measurements. Nor were SNPs significantly associated with blood pressure, obesity, cholesterol, CRP, interleukin-6, TNF-a, or leptin.

Conclusions
These novel CAD variants are not associated with CIMT and do not appear to mediate the risk of atherothrombosis through known risk factors.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalAtherosclerosis
Volume203
Issue number1
DOIs
Publication statusPublished - Mar 2009

Fingerprint

Carotid Intima-Media Thickness
Carotid Arteries
Coronary Artery Disease
Single Nucleotide Polymorphism
Phenotype
Neurofibromin 2
Stroke
Chromosomes, Human, Pair 9
Atherosclerotic Plaques
Leptin
Interleukin-6
Atherosclerosis
Software
Obesity
Cholesterol
Genotype
Genome
Blood Pressure

Keywords

  • artherosclerosis
  • cartoid arteries
  • stroke
  • genetics

Cite this

Genetic variants linked to coronary artery disease are not associated with carotid artery intima-media thickness or intermediate risk phenotypes. / Cunnington, M. S.; Mayosi, B. M.; Hall, D. H.; Avery, P. J.; Farrall, M.; Vickers, M. A.; Watkins, H.; Keavney, B.

In: Atherosclerosis, Vol. 203, No. 1, 03.2009, p. 41-44.

Research output: Contribution to journalArticle

Cunnington, M. S. ; Mayosi, B. M. ; Hall, D. H. ; Avery, P. J. ; Farrall, M. ; Vickers, M. A. ; Watkins, H. ; Keavney, B. / Genetic variants linked to coronary artery disease are not associated with carotid artery intima-media thickness or intermediate risk phenotypes. In: Atherosclerosis. 2009 ; Vol. 203, No. 1. pp. 41-44.
@article{e276d7be155343629abdf893284213e7,
title = "Genetic variants linked to coronary artery disease are not associated with carotid artery intima-media thickness or intermediate risk phenotypes",
abstract = "It is uncertain whether the novel single nucleotide polymorphisms (SNPs) that have recently been associated with coronary artery disease (CAD) in genome-wide studies also influence carotid atheroma and stroke risk. The mechanisms of their association with CAD are unknown; relationships to other cardiovascular phenotypes may give mechanistic clues. Carotid artery intima-media thickness (CIMT) is a subclinical marker of atherosclerosis associated with stroke. We investigated association of reported CAD risk variants with CIMT, and with other intermediate phenotypes that may implicate causative pathways. Methods We studied 1425 members of 248 British Caucasian families ascertained through a hypertensive proband. We genotyped CAD risk SNPs on chromosomes 9 (rs1333049, rs7044859, rs496892, rs7865618), 6 (rs6922269) and 2 (rs2943634) using TaqMan. Merlin software was used for family-based association testing. Results No significant association was found between genotype at any SNP and CIMT in 846 individuals with acceptable measurements. Nor were SNPs significantly associated with blood pressure, obesity, cholesterol, CRP, interleukin-6, TNF-a, or leptin. Conclusions These novel CAD variants are not associated with CIMT and do not appear to mediate the risk of atherothrombosis through known risk factors.",
keywords = "artherosclerosis, cartoid arteries, stroke, genetics",
author = "Cunnington, {M. S.} and Mayosi, {B. M.} and Hall, {D. H.} and Avery, {P. J.} and M. Farrall and Vickers, {M. A.} and H. Watkins and B. Keavney",
year = "2009",
month = "3",
doi = "10.1016/j.atherosclerosis.2008.06.025",
language = "English",
volume = "203",
pages = "41--44",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "ELSEVIER IRELAND LTD",
number = "1",

}

TY - JOUR

T1 - Genetic variants linked to coronary artery disease are not associated with carotid artery intima-media thickness or intermediate risk phenotypes

AU - Cunnington, M. S.

AU - Mayosi, B. M.

AU - Hall, D. H.

AU - Avery, P. J.

AU - Farrall, M.

AU - Vickers, M. A.

AU - Watkins, H.

AU - Keavney, B.

PY - 2009/3

Y1 - 2009/3

N2 - It is uncertain whether the novel single nucleotide polymorphisms (SNPs) that have recently been associated with coronary artery disease (CAD) in genome-wide studies also influence carotid atheroma and stroke risk. The mechanisms of their association with CAD are unknown; relationships to other cardiovascular phenotypes may give mechanistic clues. Carotid artery intima-media thickness (CIMT) is a subclinical marker of atherosclerosis associated with stroke. We investigated association of reported CAD risk variants with CIMT, and with other intermediate phenotypes that may implicate causative pathways. Methods We studied 1425 members of 248 British Caucasian families ascertained through a hypertensive proband. We genotyped CAD risk SNPs on chromosomes 9 (rs1333049, rs7044859, rs496892, rs7865618), 6 (rs6922269) and 2 (rs2943634) using TaqMan. Merlin software was used for family-based association testing. Results No significant association was found between genotype at any SNP and CIMT in 846 individuals with acceptable measurements. Nor were SNPs significantly associated with blood pressure, obesity, cholesterol, CRP, interleukin-6, TNF-a, or leptin. Conclusions These novel CAD variants are not associated with CIMT and do not appear to mediate the risk of atherothrombosis through known risk factors.

AB - It is uncertain whether the novel single nucleotide polymorphisms (SNPs) that have recently been associated with coronary artery disease (CAD) in genome-wide studies also influence carotid atheroma and stroke risk. The mechanisms of their association with CAD are unknown; relationships to other cardiovascular phenotypes may give mechanistic clues. Carotid artery intima-media thickness (CIMT) is a subclinical marker of atherosclerosis associated with stroke. We investigated association of reported CAD risk variants with CIMT, and with other intermediate phenotypes that may implicate causative pathways. Methods We studied 1425 members of 248 British Caucasian families ascertained through a hypertensive proband. We genotyped CAD risk SNPs on chromosomes 9 (rs1333049, rs7044859, rs496892, rs7865618), 6 (rs6922269) and 2 (rs2943634) using TaqMan. Merlin software was used for family-based association testing. Results No significant association was found between genotype at any SNP and CIMT in 846 individuals with acceptable measurements. Nor were SNPs significantly associated with blood pressure, obesity, cholesterol, CRP, interleukin-6, TNF-a, or leptin. Conclusions These novel CAD variants are not associated with CIMT and do not appear to mediate the risk of atherothrombosis through known risk factors.

KW - artherosclerosis

KW - cartoid arteries

KW - stroke

KW - genetics

U2 - 10.1016/j.atherosclerosis.2008.06.025

DO - 10.1016/j.atherosclerosis.2008.06.025

M3 - Article

VL - 203

SP - 41

EP - 44

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 1

ER -