Abstract
Osteoporosis is a common disease with a strong genetic component characterized by low bone mass, micro-architectural deterioration of bone tissue and an
increased risk of fracture. Twin and family studies have suggested that up to 85% of the variance in bone density between individuals is genetically determined and
similar studies have shown that other determinants of osteoporotic fracture risk such as ultrasound properties of bone, skeletal geometry, and bone turnover are also genetically determined.
increased risk of fracture. Twin and family studies have suggested that up to 85% of the variance in bone density between individuals is genetically determined and
similar studies have shown that other determinants of osteoporotic fracture risk such as ultrasound properties of bone, skeletal geometry, and bone turnover are also genetically determined.
| Original language | English |
|---|---|
| Pages (from-to) | 13-21 |
| Number of pages | 9 |
| Journal | Reviews in Endocrine and Metabolic Disorders |
| Volume | 2 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 13 Dec 2004 |
Keywords
- osteoporosis
- genetic
- BMD
- fracture
- polymorphism
- linkage