@article{fd23d5b569394868b28b8f24d71e2845,
title = "Genome evolution following host jumps in the Irish potato famine pathogen lineage",
abstract = "Many plant pathogens, including those in the lineage of the Irish potato famine organism Phytophthora infestans, evolve by host jumps followed by specialization. However, how host jumps affect genome evolution remains largely unknown. To determine the patterns of sequence variation in the P. infestans lineage, we resequenced six genomes of four sister species. This revealed uneven evolutionary rates across genomes with genes in repeat-rich regions showing higher rates of structural polymorphisms and positive selection. These loci are enriched in genes induced in planta, implicating host adaptation in genome evolution. Unexpectedly, genes involved in epigenetic processes formed another class of rapidly evolving residents of the gene-sparse regions. These results demonstrate that dynamic repeat-rich genome compartments underpin accelerated gene evolution following host jumps in this pathogen lineage.",
author = "Sylvain Raffaele and Farrer, {Rhys A.} and Cano, {Liliana M.} and Studholme, {David J.} and Daniel MacLean and Marco Thines and Jiang, {Rays H. Y.} and Zody, {Michael C.} and Kunjeti, {Sridhara G} and Donofrio, {Nicole M} and Meyers, {Blake C} and Chad Nusbaum and Sophien Kamoun",
note = "We thank the Broad Institute Sequencing Platform and J. Pike for sequencing; G. Kessel and V. Vleeshouwers for biomaterial; and D. Weigel, J. Dangl, and J. Ecker for useful comments. This project was funded by the Gatsby Charitable Foundation, Marie-Curie IEF contract 255104, National Research Initiative of the U.S. Department of Agriculture grant 2006-35600-16623, NSF grant EF-0523670, and research funding program LOEWE of the Ministry of Research, Science and the Arts of Hesse (Germany). Sequences are deposited in GenBank under the submission accession numbers SRA02326–2329 and SRA024355 and in the Short Read Archive under study accession numbers ERP000341–344.",
year = "2010",
month = dec,
day = "10",
doi = "10.1126/science.1193070",
language = "English",
volume = "330",
pages = "1540--1543",
journal = "Science",
issn = "0036-8075",
publisher = "AMER ASSOC ADVANCEMENT SCIENCE",
number = "6010",
}