Genome stability and the processing of damaged replication forks by RecG

Peter McGlynn, R. G. Lloyd

Research output: Contribution to journalEditorial

115 Citations (Scopus)

Abstract

Chromosomal duplication faces many blocks to replication fork progression that could destabilize the genome and prove fatal if not overcome. Overcoming such blocks requires interplay between DNA replication, recombination and repair. The Recta protein of Escherichia coli promotes rescue of damaged forks by catalysing their unwinding and conversion to Holliday junctions. Subsequent processing of this structure allows repair or bypass of the fork block, enabling replication to resume without recourse to potentially mutagenic translesion synthesis or recombination. Such direct rescue of stalled forks might help safeguard genome integrity in all organisms.

Original languageEnglish
Pages (from-to)413-419
Number of pages6
JournalTrends in Genetics
Volume18
Issue number8
DOIs
Publication statusPublished - 2002

Keywords

  • ESCHERICHIA-COLI K-12
  • BRANCH MIGRATION PROTEIN
  • STABLE DNA-REPLICATION
  • LAGGING-STRAND
  • HOLLIDAY JUNCTIONS
  • R-LOOPS
  • RECOMBINATION
  • RUVABC
  • REPAIR
  • PRIA

Cite this