Glial cell response: A Pathogenic Factor in Parkinson's Disease

Du Chu Wu, Kim Tieu, Oren Cohen, Dong-Kug Choi, Miquel Vila, Vernice Jackson-Lewis, Peter Teismann, Serge Przedborski

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The loss of these neurons is associated with a glial response composed mainly of activated microglial cells and, to a lesser extent, of reactive astrocytes. This glial response may be the source of trophic factors and can protect against reactive oxygen species and glutamate. Alternatively, this glial response can also mediate a variety of deleterious events related to the production of pro-oxidant reactive species, proinflammatory prostaglandin, and cytokines. In this review, the authors discuss the potential protective and deleterious effects of glial cells in the SNpc of PD and examine how these factors may contribute to the pathogenesis of this disease.
Original languageEnglish
Pages (from-to)551-558
Number of pages8
JournalJournal of NeuroVirology
Volume8
Issue number6
DOIs
Publication statusPublished - 1 Dec 2002

Keywords

  • Brain
  • Humans
  • Neuroglia
  • Parkinson Disease
  • Astrocyte
  • Gliosis
  • Il-1ß
  • Inos
  • Microglia
  • Mptp
  • Neurodegeneration
  • Parkinson's Disease

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    Wu, D. C., Tieu, K., Cohen, O., Choi, D-K., Vila, M., Jackson-Lewis, V., Teismann, P., & Przedborski, S. (2002). Glial cell response: A Pathogenic Factor in Parkinson's Disease. Journal of NeuroVirology, 8(6), 551-558. https://doi.org/10.1080/13550280290100905