Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy: results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trial

Neil J Howell; Houman Ashrafian; Nigel E Drury; Aaron M Ranasinghe; Hussain Contractor; Henrik Isackson; Melanie Calvert; Lynne K Williams; Nick Freemantle; David W Quinn; David Green; Michael Frenneaux; Robert S Bonser; Jorge G Mascaro; Timothy R Graham; Stephen J Rooney; Inga Wilson; Domenico Pagano

doi:10.1161/CIRCULATIONAHA.110.945170

Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy: results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trial

Neil J Howell, Houman Ashrafian, Nigel E Drury, Aaron M Ranasinghe, Hussain Contractor, Henrik Isackson, Melanie Calvert, Lynne K Williams, Nick Freemantle, David W Quinn, David Green, Michael Frenneaux, Robert S Bonser, Jorge G Mascaro, Timothy R Graham, Stephen J Rooney, Inga Wilson, Domenico Pagano

Applied Medicine

Research output: Contribution to journal › Article › peer-review

71 Citations (Scopus)

Abstract

Patients undergoing aortic valve replacement for critical aortic stenosis often have significant left ventricular hypertrophy. Left ventricular hypertrophy has been identified as an independent predictor of poor outcome after aortic valve replacement as a result of a combination of maladaptive myocardial changes and inadequate myocardial protection at the time of surgery. Glucose-insulin-potassium (GIK) is a potentially useful adjunct to myocardial protection. This study was designed to evaluate the effects of GIK infusion in patients undergoing aortic valve replacement surgery.

Original language	English
Pages (from-to)	170-177
Number of pages	8
Journal	Circulation
Volume	123
Issue number	2
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.110.945170
Publication status	Published - 2011

Keywords

AMP-activated protein kinases
acetylglucosamine
aged
aortic valve
aortic valve stenosis
cardiac output, low
double-blind method
female
glucose
heart valve prosthesis
humans
hypertrophy, left ventricular
incidence
insulin
male
middle aged
phosphatidylinositol 3-kinases
potassium
proto-oncogene proteins c-akt
risk factors
treatment outcome

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Howell, N. J., Ashrafian, H., Drury, N. E., Ranasinghe, A. M., Contractor, H., Isackson, H., Calvert, M., Williams, L. K., Freemantle, N., Quinn, D. W., Green, D., Frenneaux, M., Bonser, R. S., Mascaro, J. G., Graham, T. R., Rooney, S. J., Wilson, I., & Pagano, D. (2011). Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy: results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trial. Circulation, 123(2), 170-177. https://doi.org/10.1161/CIRCULATIONAHA.110.945170

Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy: results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trial. / Howell, Neil J; Ashrafian, Houman; Drury, Nigel E et al.
In: Circulation, Vol. 123, No. 2, 2011, p. 170-177.

Research output: Contribution to journal › Article › peer-review

Howell, NJ, Ashrafian, H, Drury, NE, Ranasinghe, AM, Contractor, H, Isackson, H, Calvert, M, Williams, LK, Freemantle, N, Quinn, DW, Green, D, Frenneaux, M, Bonser, RS, Mascaro, JG, Graham, TR, Rooney, SJ, Wilson, I & Pagano, D 2011, 'Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy: results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trial', Circulation, vol. 123, no. 2, pp. 170-177. https://doi.org/10.1161/CIRCULATIONAHA.110.945170

Howell NJ, Ashrafian H, Drury NE, Ranasinghe AM, Contractor H, Isackson H et al. Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy: results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trial. Circulation. 2011;123(2):170-177. doi: 10.1161/CIRCULATIONAHA.110.945170

Howell, Neil J ; Ashrafian, Houman ; Drury, Nigel E et al. / Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy : results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trial. In: Circulation. 2011 ; Vol. 123, No. 2. pp. 170-177.

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abstract = "Patients undergoing aortic valve replacement for critical aortic stenosis often have significant left ventricular hypertrophy. Left ventricular hypertrophy has been identified as an independent predictor of poor outcome after aortic valve replacement as a result of a combination of maladaptive myocardial changes and inadequate myocardial protection at the time of surgery. Glucose-insulin-potassium (GIK) is a potentially useful adjunct to myocardial protection. This study was designed to evaluate the effects of GIK infusion in patients undergoing aortic valve replacement surgery.",

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