Glycerophosphoinositols inhibit the ability of tumour cells to invade the extracellular matrix

Roberto Buccione, Massimiliano Baldassarre, Valentina Trapani, Carmen Catalano, Arsenio Pompeo, Anna Brancaccio, Raffaella Giavazzi, Alberto Luini, Daniela Corda

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The naturally occurring phosphoinositide metabolite, glycerophosphoinositol 4-phosphate, has recently been shown to induce rearrangements in the actin cytoskeleton through modulation of the small GTPases, Rac and Rho. Since this is directly linked to cell spreading and remodelling, we have evaluated the potential role of glycerophosphoinositol 4-phosphate and related metabolites in tumour cell invasion. The biological effects of these compounds were tested in a number of cellular activities related to cell spreading, including cell migration and cell invasion. We find that unlike other inositol-containing molecules, such as the inositol phosphates, glycerophosphoinositol and glycerophosphoinositol 4-phosphate prevent the invasion of epithelium-derived MDA-MB-231 breast carcinoma and A375MM melanoma cell lines through the extracellular matrix; this is due to a decreased ability to degrade matrix components. These data identify a specific activity of the glycerophosphoinositols that can be exploited for their development as novel anti-invasive drugs.

Original languageEnglish
Pages (from-to)470-6
Number of pages7
JournalEuropean Journal of Cancer
Volume41
Issue number3
DOIs
Publication statusPublished - Feb 2005

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Keywords

  • Actins
  • Antineoplastic Agents
  • Breast Neoplasms
  • Chemotaxis
  • Cytoskeleton
  • Extracellular Matrix
  • Female
  • Humans
  • Inositol Phosphates
  • Matrix Metalloproteinases
  • Melanoma
  • Neoplasm Invasiveness

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