Abstract
BAX/BAK activation leading to mitochondrial outer-membrane permeabilization is a key commitment point in apoptosis. Chipuk et al. now identify two sphingolipids as specific cofactors for BAX/BAK activation that lower the threshold for apoptosis-associated cytochrome c release. Association of mitochondria with other cellular membrane compartments is required for BAK/BAX exposure to these sphingolipids.
Original language | English |
---|---|
Pages (from-to) | 845-846 |
Number of pages | 2 |
Journal | Cell |
Volume | 148 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2 Mar 2012 |