Grey and white matter differences in Chronic Fatigue Syndrome

A voxel-based morphometry study

Andreas Finkelmeyer, Jiabao He, Laura Maclachlan, Stuart Watson, Peter Gallagher, Julia L. Newton, Andrew M. Blamire

Research output: Contribution to journalArticle

8 Citations (Scopus)
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Abstract

Objective
Investigate global and regional grey and white matter volumes in patients with Chronic Fatigue Syndrome (CFS) using magnetic resonance imaging (MRI) and recent voxel-based morphometry (VBM) methods.

Methods
Forty-two patients with CFS and thirty healthy volunteers were scanned on a 3-Tesla MRI scanner. Anatomical MRI scans were segmented, normalized and submitted to a VBM analysis using randomisation methods. Group differences were identified in overall segment volumes and voxel-wise in spatially normalized grey matter (GM) and white matter (WM) segments.

Results
Accounting for total intracranial volume, patients had larger GM volume and lower WM volume. The voxel-wise analysis showed increased GM volume in several structures including the amygdala and insula in the patient group. Reductions in WM volume in the patient group were seen primarily in the midbrain, pons and right temporal lobe.

Conclusion
Elevated GM volume in CFS is seen in areas related to processing of interoceptive signals and stress. Reduced WM volume in the patient group partially supports earlier findings of WM abnormalities in regions of the midbrain and brainstem.
Original languageEnglish
Pages (from-to)24-30
Number of pages7
JournalNeuroImage: Clinical
Volume17
Early online date28 Sep 2017
DOIs
Publication statusPublished - 2018

Fingerprint

Chronic Fatigue Syndrome
Magnetic Resonance Imaging
Mesencephalon
Pons
Temporal Lobe
Random Allocation
Amygdala
Brain Stem
White Matter
Gray Matter
Healthy Volunteers

Keywords

  • Chronic Fatigue Syndrome
  • Voxel-based morphometry
  • Insula
  • Amygdala
  • Midbrain

Cite this

Finkelmeyer, A., He, J., Maclachlan, L., Watson, S., Gallagher, P., Newton, J. L., & Blamire, A. M. (2018). Grey and white matter differences in Chronic Fatigue Syndrome: A voxel-based morphometry study. NeuroImage: Clinical, 17, 24-30. https://doi.org/10.1016/j.nicl.2017.09.024

Grey and white matter differences in Chronic Fatigue Syndrome : A voxel-based morphometry study. / Finkelmeyer, Andreas; He, Jiabao; Maclachlan, Laura; Watson, Stuart; Gallagher, Peter ; Newton, Julia L.; Blamire, Andrew M.

In: NeuroImage: Clinical, Vol. 17, 2018, p. 24-30.

Research output: Contribution to journalArticle

Finkelmeyer, A, He, J, Maclachlan, L, Watson, S, Gallagher, P, Newton, JL & Blamire, AM 2018, 'Grey and white matter differences in Chronic Fatigue Syndrome: A voxel-based morphometry study', NeuroImage: Clinical, vol. 17, pp. 24-30. https://doi.org/10.1016/j.nicl.2017.09.024
Finkelmeyer, Andreas ; He, Jiabao ; Maclachlan, Laura ; Watson, Stuart ; Gallagher, Peter ; Newton, Julia L. ; Blamire, Andrew M. / Grey and white matter differences in Chronic Fatigue Syndrome : A voxel-based morphometry study. In: NeuroImage: Clinical. 2018 ; Vol. 17. pp. 24-30.
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abstract = "ObjectiveInvestigate global and regional grey and white matter volumes in patients with Chronic Fatigue Syndrome (CFS) using magnetic resonance imaging (MRI) and recent voxel-based morphometry (VBM) methods.MethodsForty-two patients with CFS and thirty healthy volunteers were scanned on a 3-Tesla MRI scanner. Anatomical MRI scans were segmented, normalized and submitted to a VBM analysis using randomisation methods. Group differences were identified in overall segment volumes and voxel-wise in spatially normalized grey matter (GM) and white matter (WM) segments.ResultsAccounting for total intracranial volume, patients had larger GM volume and lower WM volume. The voxel-wise analysis showed increased GM volume in several structures including the amygdala and insula in the patient group. Reductions in WM volume in the patient group were seen primarily in the midbrain, pons and right temporal lobe.ConclusionElevated GM volume in CFS is seen in areas related to processing of interoceptive signals and stress. Reduced WM volume in the patient group partially supports earlier findings of WM abnormalities in regions of the midbrain and brainstem.",
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note = "Conflicts of interest and source of funding The authors declare no conflicts of interest. This research was funded by the Medical Research Council (MR/J002712/1). AF is supported by Research Capability Funding from the Newcastle upon Tyne Hospitals NHS Foundation Trust and the Northumberland, Tyne and Wear NHS Foundation Trust.",
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AU - Watson, Stuart

AU - Gallagher, Peter

AU - Newton, Julia L.

AU - Blamire, Andrew M.

N1 - Conflicts of interest and source of funding The authors declare no conflicts of interest. This research was funded by the Medical Research Council (MR/J002712/1). AF is supported by Research Capability Funding from the Newcastle upon Tyne Hospitals NHS Foundation Trust and the Northumberland, Tyne and Wear NHS Foundation Trust.

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N2 - ObjectiveInvestigate global and regional grey and white matter volumes in patients with Chronic Fatigue Syndrome (CFS) using magnetic resonance imaging (MRI) and recent voxel-based morphometry (VBM) methods.MethodsForty-two patients with CFS and thirty healthy volunteers were scanned on a 3-Tesla MRI scanner. Anatomical MRI scans were segmented, normalized and submitted to a VBM analysis using randomisation methods. Group differences were identified in overall segment volumes and voxel-wise in spatially normalized grey matter (GM) and white matter (WM) segments.ResultsAccounting for total intracranial volume, patients had larger GM volume and lower WM volume. The voxel-wise analysis showed increased GM volume in several structures including the amygdala and insula in the patient group. Reductions in WM volume in the patient group were seen primarily in the midbrain, pons and right temporal lobe.ConclusionElevated GM volume in CFS is seen in areas related to processing of interoceptive signals and stress. Reduced WM volume in the patient group partially supports earlier findings of WM abnormalities in regions of the midbrain and brainstem.

AB - ObjectiveInvestigate global and regional grey and white matter volumes in patients with Chronic Fatigue Syndrome (CFS) using magnetic resonance imaging (MRI) and recent voxel-based morphometry (VBM) methods.MethodsForty-two patients with CFS and thirty healthy volunteers were scanned on a 3-Tesla MRI scanner. Anatomical MRI scans were segmented, normalized and submitted to a VBM analysis using randomisation methods. Group differences were identified in overall segment volumes and voxel-wise in spatially normalized grey matter (GM) and white matter (WM) segments.ResultsAccounting for total intracranial volume, patients had larger GM volume and lower WM volume. The voxel-wise analysis showed increased GM volume in several structures including the amygdala and insula in the patient group. Reductions in WM volume in the patient group were seen primarily in the midbrain, pons and right temporal lobe.ConclusionElevated GM volume in CFS is seen in areas related to processing of interoceptive signals and stress. Reduced WM volume in the patient group partially supports earlier findings of WM abnormalities in regions of the midbrain and brainstem.

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