GROWTH MECHANISMS AND GROWTH-KINETICS OF FILAMENTOUS MICROORGANISMS

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Abstract

Filamentous microorganisms are of major biotechnological importance, being responsible for production of the majority of secondary metabolites, particularly antibiotics. Two main groups are involved, filamentous fungi and filamentous actinomycetes, particularly the streptomycetes. In terms of cellular growth mechanisms, these groups differ greatly. Eukaryotic fungi possess subcellular organelles and cytoskeletal structures directing growth while prokaryotic streptomycetes have no such cellular organization. Despite these fundamental differences, both group exhibit similar morphologies, growth patterns, growth forms, and hyphal and mycelial growth kinetics on solid media and in liquid culture both grow as dispersed mycelia and pellets. The article therefore discusses the relationship between cellular growth mechanisms and vegetative growth in both filamentous fungi and actinomycetes, the conceptual and theoretical models applicable to both groups, and the significance of such models in industrial fermentation processes.

Original languageEnglish
Pages (from-to)253-274
Number of pages22
JournalCritical Reviews in Biotechnology
Volume10
Issue number4
Publication statusPublished - 1991

Keywords

  • STREPTOMYCES-COELICOLOR A3(2)
  • MYCELIAL PELLETS
  • FREEZE-SUBSTITUTION
  • ASPERGILLUS-NIGER
  • FUNGAL COLONIES
  • HYPHAL TIP
  • SCLEROTIUM-ROLFSII
  • NEUROSPORA-CRASSA
  • DNA-REPLICATION
  • SOLID MEDIUM

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