Guideline for the diagnosis and management of vitiligo

D J Gawkrodger, Anthony Ormerod, L Shaw, I Mauri-Sole, M E Whitton, M J Watts, A V Anstey, J Ingham, K Young, Therapy Guidelines and Audit Subcommittee, British Association of Dermatologists

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Abstract

This detailed and user-friendly guideline for the diagnosis and management of vitiligo in children and adults aims to give high quality clinical advice, based on the best available evidence and expert consensus, taking into account patient choice and clinical expertise. The guideline was devised by a structured process and is intended for use by dermatologists and as a resource for interested parties including patients. Recommendations and levels of evidence have been graded according to the method developed by the Scottish Inter-Collegiate Guidelines Network. Where evidence was lacking, research recommendations were made. The types of vitiligo, process of diagnosis in primary and secondary care, and investigation of vitiligo were assessed. Treatments considered include offering no treatment other than camouflage cosmetics and sunscreens, the use of topical potent or highly potent corticosteroids, of vitamin D analogues, and of topical calcineurin inhibitors, and depigmentation with p-(benzyloxy)phenol. The use of systemic treatment, e.g. corticosteroids, ciclosporin and other immunosuppressive agents was analyzed. Phototherapy was considered, including narrowband ultraviolet B (UVB), psoralen with ultraviolet A (UVA), and khellin with UVA or UVB, along with combinations of topical preparations and various forms of UV. Surgical treatments that were assessed include full-thickness and split skin grafting, mini (punch) grafts, autologous epidermal cell suspensions, and autologous skin equivalents. The effectiveness of cognitive therapy and psychological treatments was considered. Therapeutic algorithms using grades of recommendation and levels of evidence have been produced for children and for adults with vitiligo.
Original languageEnglish
Pages (from-to)1051-1076
Number of pages26
JournalBritish Journal of Dermatology
Volume159
Issue number5
Early online date20 Oct 2008
DOIs
Publication statusPublished - 1 Nov 2008

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Keywords

  • Adult
  • Algorithms
  • Anti-Inflammatory Agents
  • Child
  • Evidence-Based Medicine
  • Humans
  • Immunosuppressive Agents
  • Psychotherapy
  • Quality of Life
  • Ultraviolet Therapy
  • Vitiligo
  • Diagnosis
  • Guidelines
  • Treatment

Cite this

Gawkrodger, D. J., Ormerod, A., Shaw, L., Mauri-Sole, I., Whitton, M. E., Watts, M. J., ... Therapy Guidelines and Audit Subcommittee, British Association of Dermatologists (2008). Guideline for the diagnosis and management of vitiligo. British Journal of Dermatology, 159(5), 1051-1076. https://doi.org/10.1111/j.1365-2133.2008.08881.x