Haplotype analysis of hemochromatosis gene polymorphisms in chronic hepatitis C virus infection: A case control study

Sina Gerayli, Alireza Pasdar, Mohammad Taghi Shakeri, Samaneh Sepahi, Seyed Mousalreza Hoseini, Mitra Ahadi, Sina Rostami, Zahra Meshkat*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background: Chronic hepatitis C virus (HCV) infection is frequently associated with elevated serum iron markers. Polymorphisms in the hemochromatosis (HFE) genes are responsible for iron accumulation in most cases of hemochromatosis, and may play a role in HCV infection. Objectives: We aimed to assess the prevalence of HFE gene polymorphisms in a group of Iranian HCV-infected patients, and to explore the association of these polymorphisms with HCV infection. Patients and Methods: HFE gene polymorphisms were examined in a total of 69 HCV patients and 69 healthy controls using polymerase chain reaction and restriction fragment length polymorphism techniques. Haplotype and diplotype analyses were performed using PHASE software. Results: In a recessive analysismodelof the His63Asp (H63D) locus(HHvs. HD+DD), theHHgenotypewasmorecommonin patients compared to controls (adjusted P = 0.012; OR = 6.42 [95% CI: 1.51 - 27.33]). Also, in a recessive analysis model of the Cys282Tyr (C282Y) locus (CC vs. CY + YY), the CC genotype was more frequent in patients compared to controls (adjusted P = 0.03; OR = 5.06 [95% CI: 1.13 - 22.06]). In addition, there was a significant association between the HC haplotype and the HCDC diplotype and HCV infection. Conclusions: Polymorphism in the hemochromatosis gene may confer some degree of risk for HCV infection, and individuals carrying the H and C alleles may be susceptible to this disease; however, a larger sample of HCV patients and healthy individuals may be necessary to further illustrate the role of these polymorphisms in HCV.

Original languageEnglish
Article numbere24675
Number of pages7
JournalIranian red crescent medical journal
Volume18
Issue number6
Early online date15 May 2016
DOIs
Publication statusPublished - Jun 2016

Keywords

  • Hemochromatosis (HFE) Gene Polymorphisms
  • Hepatitis C Virus
  • Prognosis

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