Having a baby in your 40s with assisted reproductive technology: The reproductive dilemma of autologous versus donor oocytes

Rosemarie G. Hogan*, Alex Y. Wang, Zhuoyang Li, Karin Hammarberg, Louise Johnson, Ben W. Mol, Elizabeth A. Sullivan

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Background: Increasing numbers of women ≥40 years old are accessing assisted reproductive technology (ART) due to age-related infertility. There is limited population-based evidence about the impact on the cumulative live birth rate (CLBR) of women aged ≥40 years using their own oocytes, compared to women of a similar age, using donor oocytes. Aims: To compare the CLBR for women ≥40 years undergoing ART using autologous oocytes and women of similar age using donor oocytes. Materials and Methods: This population-based retrospective cohort study used data from all women aged ≥40 years undergoing ART with donated (n = 987) or autologous oocytes (n = 19 170) in Victoria, Australia between 2009 and 2016. A discrete-time survival model was used to evaluate the CLBR following ART with donor or autologous oocytes. The odds ratio, adjusted for woman’s age; male age; parity; cause of infertility; and the associated 95% confidence intervals (CI), were calculated. The numbers needed to be exposed (NNEs) were calculated from the adjusted odds ratio (aOR) and the CLBR in the autologous group. Results: The CLBR ranged from 28.6 to 42.5% in the donor group and from 12.5% to 1.4% in the autologous group. The discrete-time survival analysis with 95% CI demonstrated significant aOR on CLBR across all ages (range aOR: 2.56, 95% CI: 1.62–4.01 to aOR: 15.40, 95% CI: 9.10–26.04). Conclusions: Women aged ≥40 years, using donor oocytes had a significantly higher CLBR than women using autologous oocytes. The findings can be used when counselling women ≥40 years about their ART treatment options and to inform public policy.

Original languageEnglish
JournalAustralian and New Zealand Journal of Obstetrics and Gynaecology
Early online date18 May 2020
DOIs
Publication statusE-pub ahead of print - 18 May 2020

Keywords

  • advanced maternal age
  • autologous oocytes
  • cumulative live birth rate
  • discrete-time analysis
  • donor oocytes
  • AUSTRALIA
  • DONATION
  • ART
  • KNOWLEDGE
  • LIVE-BIRTH-RATES
  • FERTILITY
  • CONSEQUENCES
  • POSTPONEMENT

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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