Health-related quality of life among adult HIV positive patients: assessing comprehensive themes and interrelated associations

C. den Daas; G. E.L. van den Berk; M. J.T. Kleene; E. S. de Munnik; J. G. Lijmer; K. Brinkman

doi:10.1007/s11136-019-02203-y

Health-related quality of life among adult HIV positive patients: assessing comprehensive themes and interrelated associations

C. den Daas^*, G. E.L. van den Berk, M. J.T. Kleene, E. S. de Munnik, J. G. Lijmer, K. Brinkman

^*Corresponding author for this work

Applied Health Sciences

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

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Abstract

Purpose: We selected and evaluated a comprehensive set of themes that encompass health-related quality of life (HRQOL) among HIV patients, which enables clinicians to tailor care to individual needs, follow changes over time and quantify returns on health care investments and interventions. Methods: HIV patients (N = 250) of two Dutch HIV clinics were invited to complete an online survey comprised of a set of (adaptations of) validated questionnaires measuring eight themes, including general health (SF-12), stigma (short stigma scale), social support (SSL12-I), self-esteem (SISE), sexuality problems, anxiety and depression (HADS), sleeping difficulties (SCL90-Sleep) and perceived side-effects. Results: Findings from 170 (response rate 68%) patients (Male = 159, 94.1%) showed that questionnaires had high internal consistency, and most themes significantly correlated (r’s.21 to −.69, p <.05) in the expected directions. Exploring cut-off scores shows that a significant proportion of patients score outside of the desired range on single themes (between 16.0 and 73.1%), and many patients on multiple themes simultaneously (8.9% on 5 or more themes). Regression analysis showed that social support, self-esteem and sexuality problems were associated with general health (R =.48, R² =.23, F(4,145) = 10.57, p <.001); adding anxiety and depression, sleeping difficulties and perceived side-effects explained 51.2% of the variance in total (R =.72, ∆R² =.29, F(3, 142) = 27.82, p <.001). Conclusions: We succeeded in developing a questionnaire that comprehensively assesses HRQOL. HRQOL of the majority of Dutch HIV patients could be improved. The themes strongly influenced each other, therefore insights into any of the themes could inform interventions to improve HRQOL, and increase attention to these themes in routine consultations between patients and health care professionals.

Original language	English
Pages (from-to)	2685-2694
Number of pages	10
Journal	Quality of Life Research
Volume	28
Issue number	10
Early online date	16 May 2019
DOIs	https://doi.org/10.1007/s11136-019-02203-y
Publication status	Published - Oct 2019

Bibliographical note

Acknowledgements
We would like to thank all HIV doctors, HIV nurses and clinical nurse specialists for their help with the inclusion of patients in the study. We are further grateful to all patients who filled out the questionnaires.

Keywords

Health-related quality of life
HIV
Sexuality
Social stigma
Social support
Value based health care

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "Health-related quality of life among adult HIV positive patients: assessing comprehensive themes and interrelated associations",

abstract = "Purpose: We selected and evaluated a comprehensive set of themes that encompass health-related quality of life (HRQOL) among HIV patients, which enables clinicians to tailor care to individual needs, follow changes over time and quantify returns on health care investments and interventions. Methods: HIV patients (N = 250) of two Dutch HIV clinics were invited to complete an online survey comprised of a set of (adaptations of) validated questionnaires measuring eight themes, including general health (SF-12), stigma (short stigma scale), social support (SSL12-I), self-esteem (SISE), sexuality problems, anxiety and depression (HADS), sleeping difficulties (SCL90-Sleep) and perceived side-effects. Results: Findings from 170 (response rate 68%) patients (Male = 159, 94.1%) showed that questionnaires had high internal consistency, and most themes significantly correlated (r{\textquoteright}s.21 to −.69, p <.05) in the expected directions. Exploring cut-off scores shows that a significant proportion of patients score outside of the desired range on single themes (between 16.0 and 73.1%), and many patients on multiple themes simultaneously (8.9% on 5 or more themes). Regression analysis showed that social support, self-esteem and sexuality problems were associated with general health (R =.48, R2 =.23, F(4,145) = 10.57, p <.001); adding anxiety and depression, sleeping difficulties and perceived side-effects explained 51.2% of the variance in total (R =.72, ∆R2 =.29, F(3, 142) = 27.82, p <.001). Conclusions: We succeeded in developing a questionnaire that comprehensively assesses HRQOL. HRQOL of the majority of Dutch HIV patients could be improved. The themes strongly influenced each other, therefore insights into any of the themes could inform interventions to improve HRQOL, and increase attention to these themes in routine consultations between patients and health care professionals.",

keywords = "Health-related quality of life, HIV, Sexuality, Social stigma, Social support, Value based health care",

author = "{den Daas}, C. and {van den Berk}, {G. E.L.} and Kleene, {M. J.T.} and {de Munnik}, {E. S.} and Lijmer, {J. G.} and K. Brinkman",

note = "Acknowledgements We would like to thank all HIV doctors, HIV nurses and clinical nurse specialists for their help with the inclusion of patients in the study. We are further grateful to all patients who filled out the questionnaires.",

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doi = "10.1007/s11136-019-02203-y",

language = "English",

volume = "28",

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T1 - Health-related quality of life among adult HIV positive patients

T2 - assessing comprehensive themes and interrelated associations

AU - den Daas, C.

AU - van den Berk, G. E.L.

AU - Kleene, M. J.T.

AU - de Munnik, E. S.

AU - Lijmer, J. G.

AU - Brinkman, K.

N1 - Acknowledgements We would like to thank all HIV doctors, HIV nurses and clinical nurse specialists for their help with the inclusion of patients in the study. We are further grateful to all patients who filled out the questionnaires.

PY - 2019/10

Y1 - 2019/10

N2 - Purpose: We selected and evaluated a comprehensive set of themes that encompass health-related quality of life (HRQOL) among HIV patients, which enables clinicians to tailor care to individual needs, follow changes over time and quantify returns on health care investments and interventions. Methods: HIV patients (N = 250) of two Dutch HIV clinics were invited to complete an online survey comprised of a set of (adaptations of) validated questionnaires measuring eight themes, including general health (SF-12), stigma (short stigma scale), social support (SSL12-I), self-esteem (SISE), sexuality problems, anxiety and depression (HADS), sleeping difficulties (SCL90-Sleep) and perceived side-effects. Results: Findings from 170 (response rate 68%) patients (Male = 159, 94.1%) showed that questionnaires had high internal consistency, and most themes significantly correlated (r’s.21 to −.69, p <.05) in the expected directions. Exploring cut-off scores shows that a significant proportion of patients score outside of the desired range on single themes (between 16.0 and 73.1%), and many patients on multiple themes simultaneously (8.9% on 5 or more themes). Regression analysis showed that social support, self-esteem and sexuality problems were associated with general health (R =.48, R2 =.23, F(4,145) = 10.57, p <.001); adding anxiety and depression, sleeping difficulties and perceived side-effects explained 51.2% of the variance in total (R =.72, ∆R2 =.29, F(3, 142) = 27.82, p <.001). Conclusions: We succeeded in developing a questionnaire that comprehensively assesses HRQOL. HRQOL of the majority of Dutch HIV patients could be improved. The themes strongly influenced each other, therefore insights into any of the themes could inform interventions to improve HRQOL, and increase attention to these themes in routine consultations between patients and health care professionals.

AB - Purpose: We selected and evaluated a comprehensive set of themes that encompass health-related quality of life (HRQOL) among HIV patients, which enables clinicians to tailor care to individual needs, follow changes over time and quantify returns on health care investments and interventions. Methods: HIV patients (N = 250) of two Dutch HIV clinics were invited to complete an online survey comprised of a set of (adaptations of) validated questionnaires measuring eight themes, including general health (SF-12), stigma (short stigma scale), social support (SSL12-I), self-esteem (SISE), sexuality problems, anxiety and depression (HADS), sleeping difficulties (SCL90-Sleep) and perceived side-effects. Results: Findings from 170 (response rate 68%) patients (Male = 159, 94.1%) showed that questionnaires had high internal consistency, and most themes significantly correlated (r’s.21 to −.69, p <.05) in the expected directions. Exploring cut-off scores shows that a significant proportion of patients score outside of the desired range on single themes (between 16.0 and 73.1%), and many patients on multiple themes simultaneously (8.9% on 5 or more themes). Regression analysis showed that social support, self-esteem and sexuality problems were associated with general health (R =.48, R2 =.23, F(4,145) = 10.57, p <.001); adding anxiety and depression, sleeping difficulties and perceived side-effects explained 51.2% of the variance in total (R =.72, ∆R2 =.29, F(3, 142) = 27.82, p <.001). Conclusions: We succeeded in developing a questionnaire that comprehensively assesses HRQOL. HRQOL of the majority of Dutch HIV patients could be improved. The themes strongly influenced each other, therefore insights into any of the themes could inform interventions to improve HRQOL, and increase attention to these themes in routine consultations between patients and health care professionals.

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KW - Sexuality

KW - Social stigma

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Health-related quality of life among adult HIV positive patients: assessing comprehensive themes and interrelated associations

Abstract

Bibliographical note

Keywords

UN SDGs

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