Heart failure with preserved left ventricular systolic function: a hospital cohort study

C. Berry, K. Hogg, John David Norrie, K. Stevenson, M. Brett, J. McMurray

    Research output: Contribution to journalArticle

    78 Citations (Scopus)

    Abstract

    Objective: To investigate how patients with heart failure with preserved left ventricular systolic function (LVSF) compare with patients with reduced LVSF.

    Design: Cohort study.

    Setting: Urban university hospital.

    Patients: 528 index emergency admissions with heart failure during the year 2000. Information on LVSF and follow up was available for 445 (84%) of these patients.

    Results: 130 (29%) patients had preserved LVSF ( defined as an ejection fraction. 40%). The median follow up was 814 days ( range 632 - 978 days). The average (SD) age was 72 ( 13) years. Women accounted for 62% and 45% of patients with preserved and reduced LVSF, respectively ( p = 0.001). Patients with preserved LVSF ( compared with those with reduced LVSF) had a higher prevalence of left ventricular hypertrophy (56% v 29%) and aortic valve disease ( mean gradient. 20 mm Hg; 31% v 9%). Fewer patients with preserved LVSF received an angiotensin converting enzyme inhibitor (65% v 78%, p = 0.008) or spironolactone (12% v 21%, p = 0.027). Anaemia tended to occur more often in patients with preserved LVSF than in those with reduced LVSF (43% v 33% for women, p = 0.12; 59% v 49% for men, p = 0.22). There was a similarly high prevalence of significant renal dysfunction in both groups ( estimated glomerular filtration rate < 60 ml/min/ 1.73 m(2) in 68% with preserved and 64% with reduced LVSF, p = 0.40). Mortality was similar in both groups ( preserved versus reduced 51 (39%) v 132 (42%), p = 0.51). Compared with patients with reduced LVSF, patients with preserved LVSF tended to have a lower risk of death or hospital admission for heart failure ( 56 ( 42%) v 165 (53%), p = 0.072) but a similar rate of death or readmission for any reason.

    Conclusion: Patients with preserved LVSF had more co-morbid problems than those with reduced LVSF; however, prognosis was similar for both groups.

    Original languageEnglish
    Pages (from-to)907-913
    Number of pages6
    JournalHeart
    Volume91
    Issue number7
    DOIs
    Publication statusPublished - 2005

    Keywords

    • EJECTION FRACTION
    • PROGNOSIS
    • SURVIVAL
    • OUTCOMES
    • READMISSION
    • MORTALITY
    • DETERMINANTS
    • DECLINE
    • TRENDS
    • LENGTH

    Cite this

    Berry, C., Hogg, K., Norrie, J. D., Stevenson, K., Brett, M., & McMurray, J. (2005). Heart failure with preserved left ventricular systolic function: a hospital cohort study. Heart, 91(7), 907-913. https://doi.org/10.1136/hrt.2004.041996

    Heart failure with preserved left ventricular systolic function: a hospital cohort study. / Berry, C.; Hogg, K.; Norrie, John David; Stevenson, K.; Brett, M.; McMurray, J.

    In: Heart, Vol. 91, No. 7, 2005, p. 907-913.

    Research output: Contribution to journalArticle

    Berry, C, Hogg, K, Norrie, JD, Stevenson, K, Brett, M & McMurray, J 2005, 'Heart failure with preserved left ventricular systolic function: a hospital cohort study', Heart, vol. 91, no. 7, pp. 907-913. https://doi.org/10.1136/hrt.2004.041996
    Berry, C. ; Hogg, K. ; Norrie, John David ; Stevenson, K. ; Brett, M. ; McMurray, J. / Heart failure with preserved left ventricular systolic function: a hospital cohort study. In: Heart. 2005 ; Vol. 91, No. 7. pp. 907-913.
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    abstract = "Objective: To investigate how patients with heart failure with preserved left ventricular systolic function (LVSF) compare with patients with reduced LVSF.Design: Cohort study.Setting: Urban university hospital.Patients: 528 index emergency admissions with heart failure during the year 2000. Information on LVSF and follow up was available for 445 (84{\%}) of these patients.Results: 130 (29{\%}) patients had preserved LVSF ( defined as an ejection fraction. 40{\%}). The median follow up was 814 days ( range 632 - 978 days). The average (SD) age was 72 ( 13) years. Women accounted for 62{\%} and 45{\%} of patients with preserved and reduced LVSF, respectively ( p = 0.001). Patients with preserved LVSF ( compared with those with reduced LVSF) had a higher prevalence of left ventricular hypertrophy (56{\%} v 29{\%}) and aortic valve disease ( mean gradient. 20 mm Hg; 31{\%} v 9{\%}). Fewer patients with preserved LVSF received an angiotensin converting enzyme inhibitor (65{\%} v 78{\%}, p = 0.008) or spironolactone (12{\%} v 21{\%}, p = 0.027). Anaemia tended to occur more often in patients with preserved LVSF than in those with reduced LVSF (43{\%} v 33{\%} for women, p = 0.12; 59{\%} v 49{\%} for men, p = 0.22). There was a similarly high prevalence of significant renal dysfunction in both groups ( estimated glomerular filtration rate < 60 ml/min/ 1.73 m(2) in 68{\%} with preserved and 64{\%} with reduced LVSF, p = 0.40). Mortality was similar in both groups ( preserved versus reduced 51 (39{\%}) v 132 (42{\%}), p = 0.51). Compared with patients with reduced LVSF, patients with preserved LVSF tended to have a lower risk of death or hospital admission for heart failure ( 56 ( 42{\%}) v 165 (53{\%}), p = 0.072) but a similar rate of death or readmission for any reason.Conclusion: Patients with preserved LVSF had more co-morbid problems than those with reduced LVSF; however, prognosis was similar for both groups.",
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    author = "C. Berry and K. Hogg and Norrie, {John David} and K. Stevenson and M. Brett and J. McMurray",
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    T1 - Heart failure with preserved left ventricular systolic function: a hospital cohort study

    AU - Berry, C.

    AU - Hogg, K.

    AU - Norrie, John David

    AU - Stevenson, K.

    AU - Brett, M.

    AU - McMurray, J.

    PY - 2005

    Y1 - 2005

    N2 - Objective: To investigate how patients with heart failure with preserved left ventricular systolic function (LVSF) compare with patients with reduced LVSF.Design: Cohort study.Setting: Urban university hospital.Patients: 528 index emergency admissions with heart failure during the year 2000. Information on LVSF and follow up was available for 445 (84%) of these patients.Results: 130 (29%) patients had preserved LVSF ( defined as an ejection fraction. 40%). The median follow up was 814 days ( range 632 - 978 days). The average (SD) age was 72 ( 13) years. Women accounted for 62% and 45% of patients with preserved and reduced LVSF, respectively ( p = 0.001). Patients with preserved LVSF ( compared with those with reduced LVSF) had a higher prevalence of left ventricular hypertrophy (56% v 29%) and aortic valve disease ( mean gradient. 20 mm Hg; 31% v 9%). Fewer patients with preserved LVSF received an angiotensin converting enzyme inhibitor (65% v 78%, p = 0.008) or spironolactone (12% v 21%, p = 0.027). Anaemia tended to occur more often in patients with preserved LVSF than in those with reduced LVSF (43% v 33% for women, p = 0.12; 59% v 49% for men, p = 0.22). There was a similarly high prevalence of significant renal dysfunction in both groups ( estimated glomerular filtration rate < 60 ml/min/ 1.73 m(2) in 68% with preserved and 64% with reduced LVSF, p = 0.40). Mortality was similar in both groups ( preserved versus reduced 51 (39%) v 132 (42%), p = 0.51). Compared with patients with reduced LVSF, patients with preserved LVSF tended to have a lower risk of death or hospital admission for heart failure ( 56 ( 42%) v 165 (53%), p = 0.072) but a similar rate of death or readmission for any reason.Conclusion: Patients with preserved LVSF had more co-morbid problems than those with reduced LVSF; however, prognosis was similar for both groups.

    AB - Objective: To investigate how patients with heart failure with preserved left ventricular systolic function (LVSF) compare with patients with reduced LVSF.Design: Cohort study.Setting: Urban university hospital.Patients: 528 index emergency admissions with heart failure during the year 2000. Information on LVSF and follow up was available for 445 (84%) of these patients.Results: 130 (29%) patients had preserved LVSF ( defined as an ejection fraction. 40%). The median follow up was 814 days ( range 632 - 978 days). The average (SD) age was 72 ( 13) years. Women accounted for 62% and 45% of patients with preserved and reduced LVSF, respectively ( p = 0.001). Patients with preserved LVSF ( compared with those with reduced LVSF) had a higher prevalence of left ventricular hypertrophy (56% v 29%) and aortic valve disease ( mean gradient. 20 mm Hg; 31% v 9%). Fewer patients with preserved LVSF received an angiotensin converting enzyme inhibitor (65% v 78%, p = 0.008) or spironolactone (12% v 21%, p = 0.027). Anaemia tended to occur more often in patients with preserved LVSF than in those with reduced LVSF (43% v 33% for women, p = 0.12; 59% v 49% for men, p = 0.22). There was a similarly high prevalence of significant renal dysfunction in both groups ( estimated glomerular filtration rate < 60 ml/min/ 1.73 m(2) in 68% with preserved and 64% with reduced LVSF, p = 0.40). Mortality was similar in both groups ( preserved versus reduced 51 (39%) v 132 (42%), p = 0.51). Compared with patients with reduced LVSF, patients with preserved LVSF tended to have a lower risk of death or hospital admission for heart failure ( 56 ( 42%) v 165 (53%), p = 0.072) but a similar rate of death or readmission for any reason.Conclusion: Patients with preserved LVSF had more co-morbid problems than those with reduced LVSF; however, prognosis was similar for both groups.

    KW - EJECTION FRACTION

    KW - PROGNOSIS

    KW - SURVIVAL

    KW - OUTCOMES

    KW - READMISSION

    KW - MORTALITY

    KW - DETERMINANTS

    KW - DECLINE

    KW - TRENDS

    KW - LENGTH

    U2 - 10.1136/hrt.2004.041996

    DO - 10.1136/hrt.2004.041996

    M3 - Article

    VL - 91

    SP - 907

    EP - 913

    JO - Heart

    JF - Heart

    SN - 1355-6037

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