Hederacine A and Hederacine B from Glechoma hederaceae Inhibit the growth of Colorectal Cancer Cells in vitro

Y. Kumarasamy, L. Nahar, P. Kong-Thu-Lin, Marcel Jaspars, S. D. Sarker

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The cytotoxic activity of the tropane alkaloids, hederacine A (1) and hederacine B (2), previously isolated from the methanol extract of the aerial parts of Glechoma hederaceae, was assessed by the MTT cytotoxicity assay using colon cancer cell line (CaCo-2). The IC50 values for 1 and 2 were found to be 86.6 and 301.0 mu M, respectively.

Original languageEnglish
Pages (from-to)33-35
Number of pages2
JournalNatural Product Communications
Volume1
Issue number1
Publication statusPublished - 2006

Keywords

  • glechoma hederaceae
  • Lamiaceae
  • hederacine A
  • hederacine 13
  • tropane alkaloid
  • colon cancer
  • MTT
  • STRUCTURE ELUCIDATION
  • MULTIDRUG-RESISTANCE

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