Helicobacter Pylori associated global gastric cancer burden

Sam M Mbulaiteye, Michie Hisada, Emad M El-Omar

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Helicobacter pylori infection is ubiquitous, infecting close to one-half of the world's population, but its prevalence is declining in developed countries. Chronic H. pylori infection is etiologically linked to gastric adenocarcinoma, especially non-cardia type (63% of all stomach cancer or ~5.5% of the global cancer burden: ~25% of cancers associated with infectious etiology), and to gastric mucosal associated lymphoid tissue (MALT) lymphoma, which accounts for up to 8% of all non-Hodgkin lymphoma. Epidemiological, clinical, and animal studies have established a central role for H. pylori in gastric carcinogenesis and provided insights into the mechanisms and biologic relationships between bacterial infection, host genetics, nutrition, and environmental factors. These discoveries invite strategies to prevent infection to be the logical primary goals in a multi-pronged effort to curtail suffering and death from H. pylori infection-associated cancers.
Original languageEnglish
Pages (from-to)1490-1504
Number of pages15
JournalFrontiers in Bioscience
Volume14
DOIs
Publication statusPublished - 1 Jan 2009

Keywords

  • Helicobacter pylori
  • humans
  • incidence
  • lymphoma, B-cell
  • risk factors
  • stomach neoplasms
  • virulence
  • world health
  • gastric cancer
  • African enigma
  • parasites
  • prevention
  • review
  • marginal zone

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    Mbulaiteye, S. M., Hisada, M., & El-Omar, E. M. (2009). Helicobacter Pylori associated global gastric cancer burden. Frontiers in Bioscience, 14, 1490-1504. https://doi.org/10.2741/3320