Abstract
The production of pathogenic autoantibodies in organ-specific autoimmune diseases is largely T cell dependent. For many of these diseases, the precise specificities and cytokine profiles of the T cells that respond to the corresponding autoantigens have now been identified. This knowledge has been exploited to treat some models of antibody-mediated autoimmunity using peptides corresponding to the dominant helper epitopes, giving impetus to the development of a similar approach in the equivalent human diseases.
Original language | English |
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Pages (from-to) | 664-669 |
Number of pages | 6 |
Journal | Current Opinion in Allergy and Clinical Immunology |
Volume | 12 |
Publication status | Published - 2000 |
Keywords
- STIMULATING HORMONE-RECEPTOR
- X BXSB)F1 MICE
- MYASTHENIA-GRAVIS
- HEMOLYTIC-ANEMIA
- ACETYLCHOLINE-RECEPTOR
- IN-VITRO
- THYROTROPIN-RECEPTOR
- GOODPASTURE ANTIGEN
- THROMBOCYTOPENIC PURPURA
- RHESUS POLYPEPTIDES