Helper T cells in antibody-mediated, organ-specific autoimmunity

C J Elson, R N Barker

Research output: Contribution to journalLiterature review

62 Citations (Scopus)

Abstract

The production of pathogenic autoantibodies in organ-specific autoimmune diseases is largely T cell dependent. For many of these diseases, the precise specificities and cytokine profiles of the T cells that respond to the corresponding autoantigens have now been identified. This knowledge has been exploited to treat some models of antibody-mediated autoimmunity using peptides corresponding to the dominant helper epitopes, giving impetus to the development of a similar approach in the equivalent human diseases.

Original languageEnglish
Pages (from-to)664-669
Number of pages6
JournalCurrent Opinion in Allergy and Clinical Immunology
Volume12
Publication statusPublished - 2000

Keywords

  • STIMULATING HORMONE-RECEPTOR
  • X BXSB)F1 MICE
  • MYASTHENIA-GRAVIS
  • HEMOLYTIC-ANEMIA
  • ACETYLCHOLINE-RECEPTOR
  • IN-VITRO
  • THYROTROPIN-RECEPTOR
  • GOODPASTURE ANTIGEN
  • THROMBOCYTOPENIC PURPURA
  • RHESUS POLYPEPTIDES

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