Heredity links natural hazards and human health: apolipoprotein E gene moderates self-rated health in earthquake survivors

Michael Daly, Malcolm MacLachlan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

OBJECTIVE: This study aimed to investigate the role of the apolipoprotein e4 allele in moderating the influence of an exogenous stressor, an earthquake, on health.

DESIGN: A "natural experiment" design was used where the interaction between the presence of the apolipoprotein e4 allele and the level of subjective and objective exposure to a devastating earthquake was examined in a population-based cohort of elderly Taiwanese (N = 718).

MAIN OUTCOME MEASURES: The cognitive-affective dimension of health was assessed by measures of perceived control and depression and functional limitations were assessed using measures of instrumental activities of daily living and mobility. Overall health status was gauged using a single-item measure of self-rated health.

RESULTS: Those who experienced damage to their property or were forced to move from their homes (high objective exposure) demonstrated low levels of self-rated health and somewhat lower perceived control a year later, only if they were apolipoprotein e4 carriers. Similarly, those who found the earthquake severely distressing (high subjective exposure) were shown to have low levels of functioning and low self-rated health a year later, only if they possessed the e4 allele.

CONCLUSION: Our findings suggest that genetic variation in the apolipoprotein E gene may modify the health effects of the exogenous stress of natural disaster exposure.

Original languageEnglish
Pages (from-to)228-235
Number of pages8
JournalHealth Psychology
Volume30
Issue number2
DOIs
Publication statusPublished - Mar 2011

Fingerprint

Earthquakes
Heredity
Apolipoproteins E
Survivors
Apolipoprotein E4
Health
Genes
Alleles
Disasters
Activities of Daily Living
Health Status
Outcome Assessment (Health Care)
Population

Cite this

Heredity links natural hazards and human health : apolipoprotein E gene moderates self-rated health in earthquake survivors. / Daly, Michael; MacLachlan, Malcolm.

In: Health Psychology, Vol. 30, No. 2, 03.2011, p. 228-235.

Research output: Contribution to journalArticle

@article{e60546602ebb49f8b8b4a667576a8b72,
title = "Heredity links natural hazards and human health: apolipoprotein E gene moderates self-rated health in earthquake survivors",
abstract = "OBJECTIVE: This study aimed to investigate the role of the apolipoprotein e4 allele in moderating the influence of an exogenous stressor, an earthquake, on health. DESIGN: A {"}natural experiment{"} design was used where the interaction between the presence of the apolipoprotein e4 allele and the level of subjective and objective exposure to a devastating earthquake was examined in a population-based cohort of elderly Taiwanese (N = 718). MAIN OUTCOME MEASURES: The cognitive-affective dimension of health was assessed by measures of perceived control and depression and functional limitations were assessed using measures of instrumental activities of daily living and mobility. Overall health status was gauged using a single-item measure of self-rated health. RESULTS: Those who experienced damage to their property or were forced to move from their homes (high objective exposure) demonstrated low levels of self-rated health and somewhat lower perceived control a year later, only if they were apolipoprotein e4 carriers. Similarly, those who found the earthquake severely distressing (high subjective exposure) were shown to have low levels of functioning and low self-rated health a year later, only if they possessed the e4 allele. CONCLUSION: Our findings suggest that genetic variation in the apolipoprotein E gene may modify the health effects of the exogenous stress of natural disaster exposure.",
author = "Michael Daly and Malcolm MacLachlan",
year = "2011",
month = "3",
doi = "10.1037/a0022377",
language = "English",
volume = "30",
pages = "228--235",
journal = "Health Psychology",
issn = "0278-6133",
publisher = "AMER PSYCHOLOGICAL ASSOC",
number = "2",

}

TY - JOUR

T1 - Heredity links natural hazards and human health

T2 - apolipoprotein E gene moderates self-rated health in earthquake survivors

AU - Daly, Michael

AU - MacLachlan, Malcolm

PY - 2011/3

Y1 - 2011/3

N2 - OBJECTIVE: This study aimed to investigate the role of the apolipoprotein e4 allele in moderating the influence of an exogenous stressor, an earthquake, on health. DESIGN: A "natural experiment" design was used where the interaction between the presence of the apolipoprotein e4 allele and the level of subjective and objective exposure to a devastating earthquake was examined in a population-based cohort of elderly Taiwanese (N = 718). MAIN OUTCOME MEASURES: The cognitive-affective dimension of health was assessed by measures of perceived control and depression and functional limitations were assessed using measures of instrumental activities of daily living and mobility. Overall health status was gauged using a single-item measure of self-rated health. RESULTS: Those who experienced damage to their property or were forced to move from their homes (high objective exposure) demonstrated low levels of self-rated health and somewhat lower perceived control a year later, only if they were apolipoprotein e4 carriers. Similarly, those who found the earthquake severely distressing (high subjective exposure) were shown to have low levels of functioning and low self-rated health a year later, only if they possessed the e4 allele. CONCLUSION: Our findings suggest that genetic variation in the apolipoprotein E gene may modify the health effects of the exogenous stress of natural disaster exposure.

AB - OBJECTIVE: This study aimed to investigate the role of the apolipoprotein e4 allele in moderating the influence of an exogenous stressor, an earthquake, on health. DESIGN: A "natural experiment" design was used where the interaction between the presence of the apolipoprotein e4 allele and the level of subjective and objective exposure to a devastating earthquake was examined in a population-based cohort of elderly Taiwanese (N = 718). MAIN OUTCOME MEASURES: The cognitive-affective dimension of health was assessed by measures of perceived control and depression and functional limitations were assessed using measures of instrumental activities of daily living and mobility. Overall health status was gauged using a single-item measure of self-rated health. RESULTS: Those who experienced damage to their property or were forced to move from their homes (high objective exposure) demonstrated low levels of self-rated health and somewhat lower perceived control a year later, only if they were apolipoprotein e4 carriers. Similarly, those who found the earthquake severely distressing (high subjective exposure) were shown to have low levels of functioning and low self-rated health a year later, only if they possessed the e4 allele. CONCLUSION: Our findings suggest that genetic variation in the apolipoprotein E gene may modify the health effects of the exogenous stress of natural disaster exposure.

U2 - 10.1037/a0022377

DO - 10.1037/a0022377

M3 - Article

VL - 30

SP - 228

EP - 235

JO - Health Psychology

JF - Health Psychology

SN - 0278-6133

IS - 2

ER -