Heterocyclic derivatives from natural ocurring naphthoquinones: synthesis, characterization and X-ray structure of ß-lapachone hydrazo compounds

C. E. M. Carvalho, V. F. Ferreira, A. V. Pinto, M. C. F. R. Pinto, William Thomas Alexander Harrison

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

beta-Lapachone-5-phenylhydrazone and beta-lapachone-6-phenyl-hydrazone were synthesised and characterised using H-1 and C-13 NMR, IR, and UV-visible and X-ray analyses. H-1 NMR and UV-visible spectroscopic data indicate that the hydrazo form dominates in solution. Similarly, X-ray crystallographic data indicated that the hydrazo form exists exclusively in the solid state. (C) 2002 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)209-214
Number of pages5
JournalDyes and Pigments
Volume52
DOIs
Publication statusPublished - 2002

Keywords

  • hydrazo-derivatives
  • naphthoquinone
  • beta-lapachone
  • molecular probes
  • PROSTATE-CANCER CELLS
  • TOPOISOMERASE-I
  • INDUCTION
  • APOPTOSIS

Cite this