Heterocyclic derivatives from natural ocurring naphthoquinones: synthesis, characterization and X-ray structure of ß-lapachone hydrazo compounds

C. E. M. Carvalho, V. F. Ferreira, A. V. Pinto, M. C. F. R. Pinto, William Thomas Alexander Harrison

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

beta-Lapachone-5-phenylhydrazone and beta-lapachone-6-phenyl-hydrazone were synthesised and characterised using H-1 and C-13 NMR, IR, and UV-visible and X-ray analyses. H-1 NMR and UV-visible spectroscopic data indicate that the hydrazo form dominates in solution. Similarly, X-ray crystallographic data indicated that the hydrazo form exists exclusively in the solid state. (C) 2002 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)209-214
Number of pages5
JournalDyes and Pigments
Volume52
DOIs
Publication statusPublished - 2002

Keywords

  • hydrazo-derivatives
  • naphthoquinone
  • beta-lapachone
  • molecular probes
  • PROSTATE-CANCER CELLS
  • TOPOISOMERASE-I
  • INDUCTION
  • APOPTOSIS

Cite this

Heterocyclic derivatives from natural ocurring naphthoquinones: synthesis, characterization and X-ray structure of ß-lapachone hydrazo compounds. / Carvalho, C. E. M.; Ferreira, V. F.; Pinto, A. V.; Pinto, M. C. F. R.; Harrison, William Thomas Alexander.

In: Dyes and Pigments, Vol. 52, 2002, p. 209-214.

Research output: Contribution to journalArticle

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T1 - Heterocyclic derivatives from natural ocurring naphthoquinones: synthesis, characterization and X-ray structure of ß-lapachone hydrazo compounds

AU - Carvalho, C. E. M.

AU - Ferreira, V. F.

AU - Pinto, A. V.

AU - Pinto, M. C. F. R.

AU - Harrison, William Thomas Alexander

PY - 2002

Y1 - 2002

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AB - beta-Lapachone-5-phenylhydrazone and beta-lapachone-6-phenyl-hydrazone were synthesised and characterised using H-1 and C-13 NMR, IR, and UV-visible and X-ray analyses. H-1 NMR and UV-visible spectroscopic data indicate that the hydrazo form dominates in solution. Similarly, X-ray crystallographic data indicated that the hydrazo form exists exclusively in the solid state. (C) 2002 Elsevier Science Ltd. All rights reserved.

KW - hydrazo-derivatives

KW - naphthoquinone

KW - beta-lapachone

KW - molecular probes

KW - PROSTATE-CANCER CELLS

KW - TOPOISOMERASE-I

KW - INDUCTION

KW - APOPTOSIS

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