Heterocyclic derivatives from natural ocurring naphthoquinones: synthesis, characterization and X-ray structure of ß-lapachone hydrazo compounds

C. E. M. Carvalho; V. F. Ferreira; A. V. Pinto; M. C. F. R. Pinto; William Thomas Alexander Harrison

doi:10.1016/S0143-7208(01)00097-3

Heterocyclic derivatives from natural ocurring naphthoquinones: synthesis, characterization and X-ray structure of ß-lapachone hydrazo compounds

C. E. M. Carvalho, V. F. Ferreira, A. V. Pinto, M. C. F. R. Pinto, William Thomas Alexander Harrison

Chemistry

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

beta-Lapachone-5-phenylhydrazone and beta-lapachone-6-phenyl-hydrazone were synthesised and characterised using H-1 and C-13 NMR, IR, and UV-visible and X-ray analyses. H-1 NMR and UV-visible spectroscopic data indicate that the hydrazo form dominates in solution. Similarly, X-ray crystallographic data indicated that the hydrazo form exists exclusively in the solid state. (C) 2002 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	209-214
Number of pages	5
Journal	Dyes and Pigments
Volume	52
DOIs	https://doi.org/10.1016/S0143-7208(01)00097-3
Publication status	Published - 2002

Keywords

hydrazo-derivatives
naphthoquinone
beta-lapachone
molecular probes
PROSTATE-CANCER CELLS
TOPOISOMERASE-I
INDUCTION
APOPTOSIS

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0143-7208(01)00097-3

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title = "Heterocyclic derivatives from natural ocurring naphthoquinones: synthesis, characterization and X-ray structure of {\ss}-lapachone hydrazo compounds",

abstract = "beta-Lapachone-5-phenylhydrazone and beta-lapachone-6-phenyl-hydrazone were synthesised and characterised using H-1 and C-13 NMR, IR, and UV-visible and X-ray analyses. H-1 NMR and UV-visible spectroscopic data indicate that the hydrazo form dominates in solution. Similarly, X-ray crystallographic data indicated that the hydrazo form exists exclusively in the solid state. (C) 2002 Elsevier Science Ltd. All rights reserved.",

keywords = "hydrazo-derivatives, naphthoquinone, beta-lapachone, molecular probes, PROSTATE-CANCER CELLS, TOPOISOMERASE-I, INDUCTION, APOPTOSIS",

author = "Carvalho, {C. E. M.} and Ferreira, {V. F.} and Pinto, {A. V.} and Pinto, {M. C. F. R.} and Harrison, {William Thomas Alexander}",

year = "2002",

doi = "10.1016/S0143-7208(01)00097-3",

language = "English",

volume = "52",

pages = "209--214",

journal = "Dyes and Pigments",

issn = "0143-7208",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Heterocyclic derivatives from natural ocurring naphthoquinones: synthesis, characterization and X-ray structure of ß-lapachone hydrazo compounds

AU - Carvalho, C. E. M.

AU - Ferreira, V. F.

AU - Pinto, A. V.

AU - Pinto, M. C. F. R.

AU - Harrison, William Thomas Alexander

PY - 2002

Y1 - 2002

N2 - beta-Lapachone-5-phenylhydrazone and beta-lapachone-6-phenyl-hydrazone were synthesised and characterised using H-1 and C-13 NMR, IR, and UV-visible and X-ray analyses. H-1 NMR and UV-visible spectroscopic data indicate that the hydrazo form dominates in solution. Similarly, X-ray crystallographic data indicated that the hydrazo form exists exclusively in the solid state. (C) 2002 Elsevier Science Ltd. All rights reserved.

AB - beta-Lapachone-5-phenylhydrazone and beta-lapachone-6-phenyl-hydrazone were synthesised and characterised using H-1 and C-13 NMR, IR, and UV-visible and X-ray analyses. H-1 NMR and UV-visible spectroscopic data indicate that the hydrazo form dominates in solution. Similarly, X-ray crystallographic data indicated that the hydrazo form exists exclusively in the solid state. (C) 2002 Elsevier Science Ltd. All rights reserved.

KW - hydrazo-derivatives

KW - naphthoquinone

KW - beta-lapachone

KW - molecular probes

KW - PROSTATE-CANCER CELLS

KW - TOPOISOMERASE-I

KW - INDUCTION

KW - APOPTOSIS

U2 - 10.1016/S0143-7208(01)00097-3

DO - 10.1016/S0143-7208(01)00097-3

M3 - Article

SN - 0143-7208

VL - 52

SP - 209

EP - 214

JO - Dyes and Pigments

JF - Dyes and Pigments

ER -

Heterocyclic derivatives from natural ocurring naphthoquinones: synthesis, characterization and X-ray structure of ß-lapachone hydrazo compounds

Abstract

Keywords

UN SDGs

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