Hiding in Plain Sight: Soluble Immunomodulatory Receptors

Lekh N Dahal (Corresponding Author), Herbert Schwarz, Frank J Ward

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Alternatively spliced natural soluble isoforms of immunomodulatory receptors [cytotoxic T lymphocyte antigen-4 (CTLA-4), 4-1BB, and programmed death-1 (PD-1)/PD-L1] have been overlooked in favor of their cell-surface-bound counterparts that have generated blockbuster antibodies for the treatment of cancer. We propose that the soluble variants of these receptors contribute to immune regulation and offer potential as targets for immunotherapy.

Original languageEnglish
Pages (from-to)771-774
Number of pages4
JournalTrends in Immunology
Issue number10
Early online date5 Sep 2018
Publication statusPublished - Oct 2018


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