Hierarchy of metabolic compounds based on their synthesising capacity

T. Handorf, Oliver Ebenhoeh, D. Kahn, R. Heinrich

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The concept of scopes is applied to analyse large metabolic networks. Scopes are defined as sets of metabolites that can be synthesised by a metabolic network when it is provided with given seeds (Sets of initial metabolic compounds). Thus, scopes represent synthesising capacities of the seeds in the network. A hierarchy is discussed in the sense that compounds, which are part of the scope of another compound, possess scopes themselves that are subsets of the former scope. This hierarchy is analysed by means of a directed acyclic graph. Using a simple chemical model, it is found that this hierarchy contains specific structures that can, to a large extent, be explained by the chemical composition of the participating compounds. In this way, it represents a new kind of map of metabolic networks, arranging the metabolic compounds according to their chemical capacity.
Original languageEnglish
Pages (from-to)359-363
Number of pages5
JournalIEE Proceedings. Systems Biology
Volume153
Issue number5
Publication statusPublished - 1 Sep 2006

Keywords

  • Algorithms
  • Cell Physiology
  • Computer Graphics
  • Computer Simulation
  • Inorganic Chemicals
  • Metabolism
  • Models, Biological
  • Models, Chemical
  • Organic Chemicals
  • Proteins
  • Signal Transduction
  • User-Computer Interface

Fingerprint Dive into the research topics of 'Hierarchy of metabolic compounds based on their synthesising capacity'. Together they form a unique fingerprint.

  • Cite this

    Handorf, T., Ebenhoeh, O., Kahn, D., & Heinrich, R. (2006). Hierarchy of metabolic compounds based on their synthesising capacity. IEE Proceedings. Systems Biology, 153(5), 359-363.