High frame-rate resolution of cell division during Candida albicans filamentation

Darren D. Thomson, Judith Berman, Alexandra C. Brand

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)
6 Downloads (Pure)


The commensal yeast, Candida albicans, is an opportunistic pathogen in humans and forms filaments called hyphae and pseudohyphae, in which cell division requires precise temporal and spatial control to produce mononuclear cell compartments. High-frame-rate live-cell imaging (1frame/min) revealed that nuclear division did not occur across the septal plane. We detected the presence of nucleolar fragments that may be extrachromosomal molecules carrying the ribosomal RNA genes. Cells occasionally maintained multiple nucleoli, suggesting either polyploidy, multiple nuclei and/or aneuploidy of ChrR., while the migration pattern of sister nuclei differed between unbranched and branched hyphae. The presented movie challenges and extends previous concepts of C. albicans cell division.

Original languageEnglish
Pages (from-to)54-58
Number of pages5
JournalFungal Genetics and Biology
Early online date4 Feb 2016
Publication statusPublished - Mar 2016


  • nuclear division
  • hypha
  • septum


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