High-intensity exercise attenuates postprandial lipaemia and markers of oxidative stress

Brendan Gabriel, Aivaras Ratkevicius, Patrick Gray, Michael Frenneaux, Stuart Robert Gray

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Regular exercise can reduce the risk of CVD (cardiovascular disease). Although moderate-intensity exercise can attenuate postprandial TAG (triacylglycerol), high-intensity intermittent exercise might be a more effective method to improve health. We compared the effects of high-intensity intermittent exercise and 30 min of brisk walking on postprandial TAG, soluble adhesion molecules and markers of oxidative stress. Nine men each completed three 2-day trials. On day 1, subjects rested (control), walked briskly for 30 min (walking) or performed 5×30 s maximal sprints (high-intensity). On day 2, subjects consumed a high-fat meal for breakfast and 3 h later for lunch. Blood samples were taken at various times and analysed for TAG, glucose, insulin, ICAM-1 (intracellular adhesion molecule-1), VCAM-1 (vascular adhesion molecule-1), TBARS (thiobarbituric acid- reactive substances), protein carbonyls and ß-hydroxybutyrate. On day 2 of the high-intensity trial, there was a lower (P<0.05) incremental TAG AUC (area under the curve; 6.42±2.24 mmol/l per 7 h) compared with the control trial (9.68±4.77 mmol/l per 7 h) with no differences during day 2 of the walking trial (8.98±2.84 mmol/l per 7 h). A trend (P=0.056) for a reduced total TAG AUC was also seen during the high-intensity trial (14.13±2.83 mmol/l per 7 h) compared with control (17.18±3.92 mmol/l per 7 h), walking showed no difference (16.33±3.51 mmol/l per 7 h). On day 2 of the high-intensity trial plasma TBARS and protein carbonyls were also reduced (P<0.05) when compared with the control and walking trials. In conclusion, high-intensity intermittent exercise attenuates postprandial TAG and markers of oxidative stress after the consumption of a high-fat meal.
Original languageEnglish
Pages (from-to)313-321
Number of pages9
JournalClinical Science
Volume123
Issue number5
Early online date21 Mar 2012
DOIs
Publication statusPublished - Sep 2012

Fingerprint

Triglycerides
Oxidative Stress
Walking
Exercise
Area Under Curve
Thiobarbituric Acid Reactive Substances
Meals
Fats
Hydroxybutyrates
Lunch
Breakfast
Blood Vessels
Proteins
Cardiovascular Diseases
Insulin
Glucose
Health
High-Intensity Interval Training

Keywords

  • cardiovascular disease (CVD)
  • high-intensity exercise
  • oxidative stress
  • postprandial lipaemia
  • thiobarbituric acid-reactive substances (TBARS)
  • triacylglycerol (TAG)

Cite this

Gabriel, B., Ratkevicius, A., Gray, P., Frenneaux, M., & Gray, S. R. (2012). High-intensity exercise attenuates postprandial lipaemia and markers of oxidative stress. Clinical Science, 123(5), 313-321. https://doi.org/10.1042/CS20110600

High-intensity exercise attenuates postprandial lipaemia and markers of oxidative stress. / Gabriel, Brendan; Ratkevicius, Aivaras; Gray, Patrick; Frenneaux, Michael; Gray, Stuart Robert.

In: Clinical Science, Vol. 123, No. 5, 09.2012, p. 313-321.

Research output: Contribution to journalArticle

Gabriel, B, Ratkevicius, A, Gray, P, Frenneaux, M & Gray, SR 2012, 'High-intensity exercise attenuates postprandial lipaemia and markers of oxidative stress', Clinical Science, vol. 123, no. 5, pp. 313-321. https://doi.org/10.1042/CS20110600
Gabriel, Brendan ; Ratkevicius, Aivaras ; Gray, Patrick ; Frenneaux, Michael ; Gray, Stuart Robert. / High-intensity exercise attenuates postprandial lipaemia and markers of oxidative stress. In: Clinical Science. 2012 ; Vol. 123, No. 5. pp. 313-321.
@article{c629fa6d306a4faa9cb6cc087ded1827,
title = "High-intensity exercise attenuates postprandial lipaemia and markers of oxidative stress",
abstract = "Regular exercise can reduce the risk of CVD (cardiovascular disease). Although moderate-intensity exercise can attenuate postprandial TAG (triacylglycerol), high-intensity intermittent exercise might be a more effective method to improve health. We compared the effects of high-intensity intermittent exercise and 30 min of brisk walking on postprandial TAG, soluble adhesion molecules and markers of oxidative stress. Nine men each completed three 2-day trials. On day 1, subjects rested (control), walked briskly for 30 min (walking) or performed 5×30 s maximal sprints (high-intensity). On day 2, subjects consumed a high-fat meal for breakfast and 3 h later for lunch. Blood samples were taken at various times and analysed for TAG, glucose, insulin, ICAM-1 (intracellular adhesion molecule-1), VCAM-1 (vascular adhesion molecule-1), TBARS (thiobarbituric acid- reactive substances), protein carbonyls and {\ss}-hydroxybutyrate. On day 2 of the high-intensity trial, there was a lower (P<0.05) incremental TAG AUC (area under the curve; 6.42±2.24 mmol/l per 7 h) compared with the control trial (9.68±4.77 mmol/l per 7 h) with no differences during day 2 of the walking trial (8.98±2.84 mmol/l per 7 h). A trend (P=0.056) for a reduced total TAG AUC was also seen during the high-intensity trial (14.13±2.83 mmol/l per 7 h) compared with control (17.18±3.92 mmol/l per 7 h), walking showed no difference (16.33±3.51 mmol/l per 7 h). On day 2 of the high-intensity trial plasma TBARS and protein carbonyls were also reduced (P<0.05) when compared with the control and walking trials. In conclusion, high-intensity intermittent exercise attenuates postprandial TAG and markers of oxidative stress after the consumption of a high-fat meal.",
keywords = "cardiovascular disease (CVD), high-intensity exercise, oxidative stress, postprandial lipaemia, thiobarbituric acid-reactive substances (TBARS), triacylglycerol (TAG)",
author = "Brendan Gabriel and Aivaras Ratkevicius and Patrick Gray and Michael Frenneaux and Gray, {Stuart Robert}",
year = "2012",
month = "9",
doi = "10.1042/CS20110600",
language = "English",
volume = "123",
pages = "313--321",
journal = "Clinical Science",
issn = "0143-5221",
publisher = "Portland Press Ltd.",
number = "5",

}

TY - JOUR

T1 - High-intensity exercise attenuates postprandial lipaemia and markers of oxidative stress

AU - Gabriel, Brendan

AU - Ratkevicius, Aivaras

AU - Gray, Patrick

AU - Frenneaux, Michael

AU - Gray, Stuart Robert

PY - 2012/9

Y1 - 2012/9

N2 - Regular exercise can reduce the risk of CVD (cardiovascular disease). Although moderate-intensity exercise can attenuate postprandial TAG (triacylglycerol), high-intensity intermittent exercise might be a more effective method to improve health. We compared the effects of high-intensity intermittent exercise and 30 min of brisk walking on postprandial TAG, soluble adhesion molecules and markers of oxidative stress. Nine men each completed three 2-day trials. On day 1, subjects rested (control), walked briskly for 30 min (walking) or performed 5×30 s maximal sprints (high-intensity). On day 2, subjects consumed a high-fat meal for breakfast and 3 h later for lunch. Blood samples were taken at various times and analysed for TAG, glucose, insulin, ICAM-1 (intracellular adhesion molecule-1), VCAM-1 (vascular adhesion molecule-1), TBARS (thiobarbituric acid- reactive substances), protein carbonyls and ß-hydroxybutyrate. On day 2 of the high-intensity trial, there was a lower (P<0.05) incremental TAG AUC (area under the curve; 6.42±2.24 mmol/l per 7 h) compared with the control trial (9.68±4.77 mmol/l per 7 h) with no differences during day 2 of the walking trial (8.98±2.84 mmol/l per 7 h). A trend (P=0.056) for a reduced total TAG AUC was also seen during the high-intensity trial (14.13±2.83 mmol/l per 7 h) compared with control (17.18±3.92 mmol/l per 7 h), walking showed no difference (16.33±3.51 mmol/l per 7 h). On day 2 of the high-intensity trial plasma TBARS and protein carbonyls were also reduced (P<0.05) when compared with the control and walking trials. In conclusion, high-intensity intermittent exercise attenuates postprandial TAG and markers of oxidative stress after the consumption of a high-fat meal.

AB - Regular exercise can reduce the risk of CVD (cardiovascular disease). Although moderate-intensity exercise can attenuate postprandial TAG (triacylglycerol), high-intensity intermittent exercise might be a more effective method to improve health. We compared the effects of high-intensity intermittent exercise and 30 min of brisk walking on postprandial TAG, soluble adhesion molecules and markers of oxidative stress. Nine men each completed three 2-day trials. On day 1, subjects rested (control), walked briskly for 30 min (walking) or performed 5×30 s maximal sprints (high-intensity). On day 2, subjects consumed a high-fat meal for breakfast and 3 h later for lunch. Blood samples were taken at various times and analysed for TAG, glucose, insulin, ICAM-1 (intracellular adhesion molecule-1), VCAM-1 (vascular adhesion molecule-1), TBARS (thiobarbituric acid- reactive substances), protein carbonyls and ß-hydroxybutyrate. On day 2 of the high-intensity trial, there was a lower (P<0.05) incremental TAG AUC (area under the curve; 6.42±2.24 mmol/l per 7 h) compared with the control trial (9.68±4.77 mmol/l per 7 h) with no differences during day 2 of the walking trial (8.98±2.84 mmol/l per 7 h). A trend (P=0.056) for a reduced total TAG AUC was also seen during the high-intensity trial (14.13±2.83 mmol/l per 7 h) compared with control (17.18±3.92 mmol/l per 7 h), walking showed no difference (16.33±3.51 mmol/l per 7 h). On day 2 of the high-intensity trial plasma TBARS and protein carbonyls were also reduced (P<0.05) when compared with the control and walking trials. In conclusion, high-intensity intermittent exercise attenuates postprandial TAG and markers of oxidative stress after the consumption of a high-fat meal.

KW - cardiovascular disease (CVD)

KW - high-intensity exercise

KW - oxidative stress

KW - postprandial lipaemia

KW - thiobarbituric acid-reactive substances (TBARS)

KW - triacylglycerol (TAG)

U2 - 10.1042/CS20110600

DO - 10.1042/CS20110600

M3 - Article

C2 - 22435779

VL - 123

SP - 313

EP - 321

JO - Clinical Science

JF - Clinical Science

SN - 0143-5221

IS - 5

ER -