Hippocampal theta rhythm and its coupling with gamma oscillations require fast inhibition onto parvalbumin-positive interneurons

Peer Wulff, Alexey A Ponomarenko, Marlene Bartos, Tatiana M Korotkova, Elke C Fuchs, Florian Bähner, Martin Both, Adriano B L Tort, Nancy J Kopell, William Wisden, Hannah Monyer

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222 Citations (Scopus)

Abstract

Hippocampal theta (5-10 Hz) and gamma (35-85 Hz) oscillations depend on an inhibitory network of GABAergic interneurons. However, the lack of methods for direct and cell-type-specific interference with inhibition has prevented better insights that help link synaptic and cellular properties with network function. Here, we generated genetically modified mice (PV-Deltagamma(2)) in which synaptic inhibition was ablated in parvalbumin-positive (PV+) interneurons. Hippocampal local field potential and unit recordings in the CA1 area of freely behaving mice revealed that theta rhythm was strongly reduced in these mice. The characteristic coupling of theta and gamma oscillations was strongly altered in PV-Deltagamma(2) mice more than could be accounted for by the reduction in theta rhythm only. Surprisingly, gamma oscillations were not altered. These data indicate that synaptic inhibition onto PV+ interneurons is indispensable for theta- and its coupling to gamma oscillations but not for rhythmic gamma-activity in the hippocampus. Similar alterations in rhythmic activity were obtained in a computational hippocampal network model mimicking the genetic modification, suggesting that intrahippocampal networks might contribute to these effects.
Original languageEnglish
Pages (from-to)3561-3566
Number of pages6
JournalPNAS
Volume106
Issue number9
Early online date9 Feb 2009
DOIs
Publication statusPublished - 3 Mar 2009

Keywords

  • Animals
  • Behavior, Animal
  • Electrophysiology
  • Hippocampus
  • Interneurons
  • Mice
  • Models, Neurological
  • Parvalbumins
  • Patch-Clamp Techniques
  • Protein Subunits
  • Receptors, GABA-A
  • Synapses
  • Theta Rhythm
  • Time Factors
  • compartmental model
  • GABA
  • GABAA receptor
  • knockout
  • network synchrony

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    Wulff, P., Ponomarenko, A. A., Bartos, M., Korotkova, T. M., Fuchs, E. C., Bähner, F., Both, M., Tort, A. B. L., Kopell, N. J., Wisden, W., & Monyer, H. (2009). Hippocampal theta rhythm and its coupling with gamma oscillations require fast inhibition onto parvalbumin-positive interneurons. PNAS, 106(9), 3561-3566. https://doi.org/10.1073/pnas.0813176106