(±)-Hippolide J – A Pair of Unusual Antifungal Enantiomeric Sesterterpenoids from the Marine Sponge Hippospongia lachne

Wei Hua Jiao, Li Li Hong, Jia Bao Sun, Shu Juan Piao, Guo Dong Chen, Hai Deng, Shu Ping Wang, Fan Yang, Hou Wen Lin*

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A pair of enantiomeric sesterterpenoids, (±)-hippolide J (1a and 1b), were isolated from the marine sponge Hippospongia lachne collected from the South China Sea. The racemic mixture was resolved into a pair of enantiomers, (–)-1a and (+)-1b, by chiral HPLC separation. The structures of the enantiomers were determined through ESI-HRMS and NMR spectroscopic analysis, and their absolute configurations were determined by comparison between the calculated and experimental electronic circular dichroism (ECD) spectra. Hippolide J (1) features an unusual bicyclo[4.2.0]octene core and contains three functional groups, namely, a hydroxymethyl group, an α,β-unsaturated γ-lactone fragment, and a characteristic prenyl side-chain. The evaluation of the antifungal activity of (–)-1a and (+)-1b revealed that both show potent antifungal activity against three strains of hospital-acquired pathogenic fungi, namely, Candida albicans SC5314, Candida glabrata 537, and Trichophyton rubrum Cmccftla, with MIC50 (minimum concentration to give 50 % inhibition) values of 0.125–0.25 µg/mL.

Original languageEnglish
Pages (from-to)3421-3426
Number of pages6
JournalEuropean Journal of Organic Chemistry
Volume2017
Issue number24
Early online date26 Jun 2017
DOIs
Publication statusPublished - 30 Jun 2017

Keywords

  • Antifungal agents
  • Chiral separation
  • Marine sponges
  • Natural products
  • Terpenoids

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of '(±)-Hippolide J – A Pair of Unusual Antifungal Enantiomeric Sesterterpenoids from the Marine Sponge Hippospongia lachne'. Together they form a unique fingerprint.

  • Cite this