Hormone therapy and intraocular pressure in nonglaucomatous eyes

Naing L Tint, Philip Alexander, Khin M. Tint, George T. Vasileiadis, Aaron M. Yeung, Augusto Azuara-Blanco

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Objective: The influence of sex hormones on intraocular pressure (IOP) has been the focus of recent debate. Previous studies investigating the effects of hormone therapy (HT) on IOP in postmenopausal women have produced conflicting results but have been limited by small numbers of participants. The aim of our study was to compare IOP in women without glaucoma taking HT with those not taking HT.

Methods: A prospective cross-sectional study of postmenopausal women visiting a single ophthalmic medical practitioner was conducted. All women with a history of intraocular disease, a family history of glaucoma, or refractive error exceeding ±5 diopters were excluded. Applanation tonometry was used to measure IOP, and participants were then asked if they were current HT users.

Results: A total of 263 participants were recruited, of whom 91 reported current use of HT; 172 had never used HT. Within the HT group, 33 were taking an estrogen-therapy and 58 were taking a estrogen-progesterone therapy. Mean IOP in the HT group was significantly lower than that in the non-HT group; the mean difference was 1.41 mm Hg (P < 0.001). This difference remained statistically significant after statistical correction for age, use of systemic ß-blockers, and time of IOP measurement. There was no significant difference in mean IOP between women taking combined versus those taking estrogen-only preparations.

Conclusions: Our study showed that IOP was significantly lower in women taking HT than in those who had never taken HT, even after removing other possible influences on IOP. The IOP-lowering effect of HT deserves further investigation to explore whether it may represent a possible new therapeutic modality for glaucoma.
Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalMenopause
Volume17
Issue number1
DOIs
Publication statusPublished - Jan 2010

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Intraocular Pressure
Hormones
Therapeutics
Group Psychotherapy
Glaucoma
Estrogens
Refractive Errors
Manometry
Gonadal Steroid Hormones
Progesterone
Cross-Sectional Studies

Keywords

  • aged
  • cross-sectional studies
  • estrogen replacement therapy
  • estrogens
  • female
  • humans
  • intraocular pressure
  • middle aged
  • progesterone
  • prospective studies
  • glaucoma
  • hormone therapy
  • menopause

Cite this

Tint, N. L., Alexander, P., Tint, K. M., Vasileiadis, G. T., Yeung, A. M., & Azuara-Blanco, A. (2010). Hormone therapy and intraocular pressure in nonglaucomatous eyes. Menopause, 17(1), 157-160. https://doi.org/10.1097/gme.0b013e3181b82fb4

Hormone therapy and intraocular pressure in nonglaucomatous eyes. / Tint, Naing L; Alexander, Philip; Tint, Khin M.; Vasileiadis, George T.; Yeung, Aaron M.; Azuara-Blanco, Augusto.

In: Menopause, Vol. 17, No. 1, 01.2010, p. 157-160.

Research output: Contribution to journalArticle

Tint, NL, Alexander, P, Tint, KM, Vasileiadis, GT, Yeung, AM & Azuara-Blanco, A 2010, 'Hormone therapy and intraocular pressure in nonglaucomatous eyes', Menopause, vol. 17, no. 1, pp. 157-160. https://doi.org/10.1097/gme.0b013e3181b82fb4
Tint NL, Alexander P, Tint KM, Vasileiadis GT, Yeung AM, Azuara-Blanco A. Hormone therapy and intraocular pressure in nonglaucomatous eyes. Menopause. 2010 Jan;17(1):157-160. https://doi.org/10.1097/gme.0b013e3181b82fb4
Tint, Naing L ; Alexander, Philip ; Tint, Khin M. ; Vasileiadis, George T. ; Yeung, Aaron M. ; Azuara-Blanco, Augusto. / Hormone therapy and intraocular pressure in nonglaucomatous eyes. In: Menopause. 2010 ; Vol. 17, No. 1. pp. 157-160.
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