Host-microbe interactions: innate pattern recognition of fungal pathogens

Frank L. van de Veerdonk, Bart Jan Kullberg, Jos W. M. van der Meer, Neil A. R. Gow, Mihai G. Netea

Research output: Contribution to journalLiterature review

116 Citations (Scopus)

Abstract

The recognition of fungi is mediated by germline pattern recognition receptors (PRRs) such as Toll-like receptors and lectin receptors that interact with conserved structures of the microorganisms, the pathogen-associated molecular patterns (PAMPs). Subsequently, PRRs activate intracellular signals that collaborate for the efficient activation of the host defense. The specificity of these responses is achieved through the activation of a particular mosaic of PRRs, that is determined by the available fungal PAMPs and the innate immune cells involved. This will determine a divergence of the final type of reaction, and in this way the innate host defense has the capability to deliver tailored responses to each pathogen.

Original languageEnglish
Pages (from-to)305-312
Number of pages8
JournalCurrent Opinion in Microbiology
Volume11
Issue number4
Early online date17 Jul 2008
DOIs
Publication statusPublished - Aug 2008

Keywords

  • toll-like receptors
  • C-type lectin
  • Mannan-binding lectin
  • aspergillus-fumigatus conidia
  • regulatory T-cells
  • candida-albicans
  • cryptococcus-neoformans
  • dendritic cells
  • mannose receptor
  • beta-glucan

Cite this

van de Veerdonk, F. L., Kullberg, B. J., van der Meer, J. W. M., Gow, N. A. R., & Netea, M. G. (2008). Host-microbe interactions: innate pattern recognition of fungal pathogens. Current Opinion in Microbiology, 11(4), 305-312. https://doi.org/10.1016/j.mib.2008.06.002