Wie groß sind die kleinen genetischen Risiken?

Translated title of the contribution: How big are the small genetic risks?

I. M. Heid*, T. W. Winkler, F. Grassmann, B. H.F. Weber

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

While family studies are ideal to pinpoint strong genetic risk effects, genome-wide association studies in unrelated individuals are particularly successful in identifying moderate and small genetic risks for multifactorial diseases and disease-relevant quantitative parameters. Here, we present how the genetic risk for such variants is computed and what models are used to derive cumulative genetic risk. Using the examples of obesity, diabetes, and age-related macular degeneration, we illustrate how these risks are computed and tackle the question of how big the small genetic risks are.

Translated title of the contributionHow big are the small genetic risks?
Original languageGerman
Pages (from-to)377-384
Number of pages8
JournalMedizinische Genetik
Volume23
Issue number3
DOIs
Publication statusPublished - 1 Sep 2011

Keywords

  • Age-related macular degeneration
  • Genetic association studies
  • Linear models
  • Obesity
  • Risk assessment

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