How important is urinary cytology in the diagnosis of urological malignancies?

Ghulam Nabi, D. R. Greene, Maire O'Donnell

    Research output: Contribution to journalArticle

    47 Citations (Scopus)

    Abstract

    Objective: To audit clinical usefulness of urine cytology examination in a subspecialised urological unit setting.

    Patients and Methods: Data from the hospital information support system on urinary cytology examinations carried out at one centre was audited over a period of 15 months. Source of urine cytology specimens, clinical profile of patients and the findings of urinary cytology were analysed and collated.

    Results: A total of 1400 urinary cytology specimen on 900 patients were requested during 15 months study period. Urologists requested 1092 (78%) and non-urologists (general practitioners, physician or general surgeons) requested 318 (22%) specimens. The majority of specimens, 1115 (80%) did not show any cytological evidence of malignancy. 83 specimens (6%) showed cytological evidence of malignant cells consistent with origin from a urothelial malignancy. Among this group 87% (72) were more than 50 years of age and 60 (72%) had history of gross heamaturia. 159 (11.35) cases were reported as being suspicious of malignancy or showing atypical cells requiring further evidence. A total of 43 (3.04%) specimens were poorly preserved or insufficient for diagnosis. The positivity rate amongst urologist and non-urologists request was 56% and 6% respectively (p = 0.00001 value). The source in 37 (86%) specimens reported, as poorly preserved or insufficient for diagnosis was non-urologists compared to 6 (14%) from urologists with significant p value (0.00001).

    Conclusions: Urinary cytology for malignant cells is a contributory investigation in the diagnosis of urological malignancy. It should be only ordered in the proper clinical situation. (C) 2003 Elsevier Science B.V. All rights reserved.

    Original languageEnglish
    Pages (from-to)632-636
    Number of pages4
    JournalEuropean Urology
    Volume43
    Issue number6
    DOIs
    Publication statusPublished - 2003

    Keywords

    • cytology
    • malignant cells
    • malignancy
    • urinary bladder
    • RECURRENT BLADDER-TUMORS
    • VOIDED URINE
    • CANCER
    • MANAGEMENT
    • HISTOPATHOLOGY
    • WORKLOAD
    • NMP22

    Cite this

    How important is urinary cytology in the diagnosis of urological malignancies? / Nabi, Ghulam; Greene, D. R.; O'Donnell, Maire.

    In: European Urology, Vol. 43, No. 6, 2003, p. 632-636.

    Research output: Contribution to journalArticle

    Nabi, Ghulam ; Greene, D. R. ; O'Donnell, Maire. / How important is urinary cytology in the diagnosis of urological malignancies?. In: European Urology. 2003 ; Vol. 43, No. 6. pp. 632-636.
    @article{96de3e2109db491f9cdaf692c1a1b900,
    title = "How important is urinary cytology in the diagnosis of urological malignancies?",
    abstract = "Objective: To audit clinical usefulness of urine cytology examination in a subspecialised urological unit setting.Patients and Methods: Data from the hospital information support system on urinary cytology examinations carried out at one centre was audited over a period of 15 months. Source of urine cytology specimens, clinical profile of patients and the findings of urinary cytology were analysed and collated.Results: A total of 1400 urinary cytology specimen on 900 patients were requested during 15 months study period. Urologists requested 1092 (78{\%}) and non-urologists (general practitioners, physician or general surgeons) requested 318 (22{\%}) specimens. The majority of specimens, 1115 (80{\%}) did not show any cytological evidence of malignancy. 83 specimens (6{\%}) showed cytological evidence of malignant cells consistent with origin from a urothelial malignancy. Among this group 87{\%} (72) were more than 50 years of age and 60 (72{\%}) had history of gross heamaturia. 159 (11.35) cases were reported as being suspicious of malignancy or showing atypical cells requiring further evidence. A total of 43 (3.04{\%}) specimens were poorly preserved or insufficient for diagnosis. The positivity rate amongst urologist and non-urologists request was 56{\%} and 6{\%} respectively (p = 0.00001 value). The source in 37 (86{\%}) specimens reported, as poorly preserved or insufficient for diagnosis was non-urologists compared to 6 (14{\%}) from urologists with significant p value (0.00001).Conclusions: Urinary cytology for malignant cells is a contributory investigation in the diagnosis of urological malignancy. It should be only ordered in the proper clinical situation. (C) 2003 Elsevier Science B.V. All rights reserved.",
    keywords = "cytology, malignant cells, malignancy, urinary bladder, RECURRENT BLADDER-TUMORS, VOIDED URINE, CANCER, MANAGEMENT, HISTOPATHOLOGY, WORKLOAD, NMP22",
    author = "Ghulam Nabi and Greene, {D. R.} and Maire O'Donnell",
    year = "2003",
    doi = "10.1016/S0302-2838(03)00147-7",
    language = "English",
    volume = "43",
    pages = "632--636",
    journal = "European Urology",
    issn = "0302-2838",
    publisher = "Elsevier",
    number = "6",

    }

    TY - JOUR

    T1 - How important is urinary cytology in the diagnosis of urological malignancies?

    AU - Nabi, Ghulam

    AU - Greene, D. R.

    AU - O'Donnell, Maire

    PY - 2003

    Y1 - 2003

    N2 - Objective: To audit clinical usefulness of urine cytology examination in a subspecialised urological unit setting.Patients and Methods: Data from the hospital information support system on urinary cytology examinations carried out at one centre was audited over a period of 15 months. Source of urine cytology specimens, clinical profile of patients and the findings of urinary cytology were analysed and collated.Results: A total of 1400 urinary cytology specimen on 900 patients were requested during 15 months study period. Urologists requested 1092 (78%) and non-urologists (general practitioners, physician or general surgeons) requested 318 (22%) specimens. The majority of specimens, 1115 (80%) did not show any cytological evidence of malignancy. 83 specimens (6%) showed cytological evidence of malignant cells consistent with origin from a urothelial malignancy. Among this group 87% (72) were more than 50 years of age and 60 (72%) had history of gross heamaturia. 159 (11.35) cases were reported as being suspicious of malignancy or showing atypical cells requiring further evidence. A total of 43 (3.04%) specimens were poorly preserved or insufficient for diagnosis. The positivity rate amongst urologist and non-urologists request was 56% and 6% respectively (p = 0.00001 value). The source in 37 (86%) specimens reported, as poorly preserved or insufficient for diagnosis was non-urologists compared to 6 (14%) from urologists with significant p value (0.00001).Conclusions: Urinary cytology for malignant cells is a contributory investigation in the diagnosis of urological malignancy. It should be only ordered in the proper clinical situation. (C) 2003 Elsevier Science B.V. All rights reserved.

    AB - Objective: To audit clinical usefulness of urine cytology examination in a subspecialised urological unit setting.Patients and Methods: Data from the hospital information support system on urinary cytology examinations carried out at one centre was audited over a period of 15 months. Source of urine cytology specimens, clinical profile of patients and the findings of urinary cytology were analysed and collated.Results: A total of 1400 urinary cytology specimen on 900 patients were requested during 15 months study period. Urologists requested 1092 (78%) and non-urologists (general practitioners, physician or general surgeons) requested 318 (22%) specimens. The majority of specimens, 1115 (80%) did not show any cytological evidence of malignancy. 83 specimens (6%) showed cytological evidence of malignant cells consistent with origin from a urothelial malignancy. Among this group 87% (72) were more than 50 years of age and 60 (72%) had history of gross heamaturia. 159 (11.35) cases were reported as being suspicious of malignancy or showing atypical cells requiring further evidence. A total of 43 (3.04%) specimens were poorly preserved or insufficient for diagnosis. The positivity rate amongst urologist and non-urologists request was 56% and 6% respectively (p = 0.00001 value). The source in 37 (86%) specimens reported, as poorly preserved or insufficient for diagnosis was non-urologists compared to 6 (14%) from urologists with significant p value (0.00001).Conclusions: Urinary cytology for malignant cells is a contributory investigation in the diagnosis of urological malignancy. It should be only ordered in the proper clinical situation. (C) 2003 Elsevier Science B.V. All rights reserved.

    KW - cytology

    KW - malignant cells

    KW - malignancy

    KW - urinary bladder

    KW - RECURRENT BLADDER-TUMORS

    KW - VOIDED URINE

    KW - CANCER

    KW - MANAGEMENT

    KW - HISTOPATHOLOGY

    KW - WORKLOAD

    KW - NMP22

    U2 - 10.1016/S0302-2838(03)00147-7

    DO - 10.1016/S0302-2838(03)00147-7

    M3 - Article

    VL - 43

    SP - 632

    EP - 636

    JO - European Urology

    JF - European Urology

    SN - 0302-2838

    IS - 6

    ER -