Human CD8+ cell non-cytolytic anti-HIV activity mediated by a novel cytokine

D. J. Blackbourn, C. Mackewicz, E. Barker, J. A. Levy*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Major histocompatibility complex (MHC)-restricted CD8 + cytotoxic T lymphocytes (CTL) mediate one of the conventional cellular immune responses to virus-infected cells. The role of this class of cells in viral infections has been reviewed in the present forum by Ada and colleagues.
Our laboratory has examined another antiviral activity of CD8 ÷ cells: non-cytolytic suppression of human immunodeficiency virus (HIV) replication (Walker et al., 1986) which is the subject of the present summary.
Original languageEnglish
Pages (from-to)653-659
Number of pages7
JournalResearch in Immunology
Volume145
Issue number8-9
DOIs
Publication statusPublished - 1994

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