Objective. - To assess disease progression in baboons (Papio cynocephalus) that were infected with two human immunodeficiency virus-2 (HIV-2) isolates. Methods. - Eight baboons were inoculated intravenously with either HIV-2(UC2) or HIV-2(UC14) and were followed for a 2- to 7-year period of observation. Results. - Six of 8 baboons showed lymphadenopathy and other signs of HIV-related disease, 3 of 8 baboons had an acute phase CD4+ T-cell decline, and 2 of 5 baboons infected with the HIV-2(UC2) isolate progressed to an acquired immunodeficiency syndrome-like disease. Human immunodeficiency virus-2-specific pathology in lymphatic tissues included follicular lysis, vascular proliferation, and lymphoid depletion. Both neutralizing antibodies and a CD8+ T-cell antiviral response were associated with resistance to disease. Conclusions. - Disease progression and the development of acquired immunodeficiency syndrome in HIV-2-infected baboons have similarities to human HIV infections.
|Number of pages||11|
|Journal||Archives of Pathology and Laboratory Medicine|
|Publication status||Published - Jun 1998|