Human papillomavirus infection in women with and without cervical cancer in Karachi, Pakistan

S A Raza, S Franceschi, S Pallardy, F R Malik, B I Avan, A Zafar, S H Ali, S Pervez, S Serajuddaula, P J F Snijders, F J van Kemenade, C J L M Meijer, S Shershah, G M Clifford

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Abstract

BACKGROUND: No data exist on the population prevalence of, or risk factors for, human papillomavirus (HPV) infection in predominantly Muslim countries in Asia.

METHODS: Cervical specimens were obtained from 899 married women aged 15-59 years from the general population of Karachi, Pakistan and from 91 locally diagnosed invasive cervical cancers (ICCs). HPV was detected using a GP5+/6+ PCR-based assay.

RESULTS: The prevalence of HPV in the general population was 2.8%, with no evidence of higher HPV prevalence in young women. The positivity of HPV was associated with women's lifetime number of sexual partners, but particularly with the age difference between spouses and other husbands' characteristics, such as extramarital sexual relationships and regular absence from home. The HPV16/18 accounted for 24 and 88% of HPV-positive women in the general population and ICC, respectively.

CONCLUSION: Cervical cancer prevention policies should take into account the low HPV prevalence and low acceptability of gynaecological examination in this population.
Original languageEnglish
Pages (from-to)1657-1660
Number of pages4
JournalBritish Journal of Cancer
Volume102
Issue number11
DOIs
Publication statusPublished - 20 Apr 2010

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Papillomavirus Infections
Pakistan
Uterine Cervical Neoplasms
Population
Spouses
Islam
Gynecological Examination
Sexual Partners
Polymerase Chain Reaction

Keywords

  • adolescent
  • adult
  • cervical intraepithelial neoplasia
  • cervix uteri
  • DNA, viral
  • female
  • humans
  • middle aged
  • Pakistan
  • papillomaviridae
  • papillomavirus infections
  • prevalence
  • uterine cervical neoplasms
  • vaginal smears
  • young adult

Cite this

Raza, S. A., Franceschi, S., Pallardy, S., Malik, F. R., Avan, B. I., Zafar, A., ... Clifford, G. M. (2010). Human papillomavirus infection in women with and without cervical cancer in Karachi, Pakistan. British Journal of Cancer, 102(11), 1657-1660. https://doi.org/10.1038/sj.bjc.6605664

Human papillomavirus infection in women with and without cervical cancer in Karachi, Pakistan. / Raza, S A; Franceschi, S; Pallardy, S; Malik, F R; Avan, B I; Zafar, A; Ali, S H; Pervez, S; Serajuddaula, S; Snijders, P J F; van Kemenade, F J; Meijer, C J L M; Shershah, S; Clifford, G M.

In: British Journal of Cancer, Vol. 102, No. 11, 20.04.2010, p. 1657-1660.

Research output: Contribution to journalArticle

Raza, SA, Franceschi, S, Pallardy, S, Malik, FR, Avan, BI, Zafar, A, Ali, SH, Pervez, S, Serajuddaula, S, Snijders, PJF, van Kemenade, FJ, Meijer, CJLM, Shershah, S & Clifford, GM 2010, 'Human papillomavirus infection in women with and without cervical cancer in Karachi, Pakistan', British Journal of Cancer, vol. 102, no. 11, pp. 1657-1660. https://doi.org/10.1038/sj.bjc.6605664
Raza SA, Franceschi S, Pallardy S, Malik FR, Avan BI, Zafar A et al. Human papillomavirus infection in women with and without cervical cancer in Karachi, Pakistan. British Journal of Cancer. 2010 Apr 20;102(11):1657-1660. https://doi.org/10.1038/sj.bjc.6605664
Raza, S A ; Franceschi, S ; Pallardy, S ; Malik, F R ; Avan, B I ; Zafar, A ; Ali, S H ; Pervez, S ; Serajuddaula, S ; Snijders, P J F ; van Kemenade, F J ; Meijer, C J L M ; Shershah, S ; Clifford, G M. / Human papillomavirus infection in women with and without cervical cancer in Karachi, Pakistan. In: British Journal of Cancer. 2010 ; Vol. 102, No. 11. pp. 1657-1660.
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abstract = "BACKGROUND: No data exist on the population prevalence of, or risk factors for, human papillomavirus (HPV) infection in predominantly Muslim countries in Asia. METHODS: Cervical specimens were obtained from 899 married women aged 15-59 years from the general population of Karachi, Pakistan and from 91 locally diagnosed invasive cervical cancers (ICCs). HPV was detected using a GP5+/6+ PCR-based assay. RESULTS: The prevalence of HPV in the general population was 2.8{\%}, with no evidence of higher HPV prevalence in young women. The positivity of HPV was associated with women's lifetime number of sexual partners, but particularly with the age difference between spouses and other husbands' characteristics, such as extramarital sexual relationships and regular absence from home. The HPV16/18 accounted for 24 and 88{\%} of HPV-positive women in the general population and ICC, respectively. CONCLUSION: Cervical cancer prevention policies should take into account the low HPV prevalence and low acceptability of gynaecological examination in this population.",
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