Human papillomavirus infection in women with and without cervical cancer in Karachi, Pakistan

S A Raza; S Franceschi; S Pallardy; F R Malik; B I Avan; A Zafar; S H Ali; S Pervez; S Serajuddaula; P J F Snijders; F J van Kemenade; C J L M Meijer; S Shershah; G M Clifford

doi:10.1038/sj.bjc.6605664

Human papillomavirus infection in women with and without cervical cancer in Karachi, Pakistan

S A Raza, S Franceschi, S Pallardy, F R Malik, B I Avan, A Zafar, S H Ali, S Pervez, S Serajuddaula, P J F Snijders, F J van Kemenade, C J L M Meijer, S Shershah, G M Clifford

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Abstract

BACKGROUND: No data exist on the population prevalence of, or risk factors for, human papillomavirus (HPV) infection in predominantly Muslim countries in Asia.

METHODS: Cervical specimens were obtained from 899 married women aged 15-59 years from the general population of Karachi, Pakistan and from 91 locally diagnosed invasive cervical cancers (ICCs). HPV was detected using a GP5+/6+ PCR-based assay.

RESULTS: The prevalence of HPV in the general population was 2.8%, with no evidence of higher HPV prevalence in young women. The positivity of HPV was associated with women's lifetime number of sexual partners, but particularly with the age difference between spouses and other husbands' characteristics, such as extramarital sexual relationships and regular absence from home. The HPV16/18 accounted for 24 and 88% of HPV-positive women in the general population and ICC, respectively.

CONCLUSION: Cervical cancer prevention policies should take into account the low HPV prevalence and low acceptability of gynaecological examination in this population.

Original language	English
Pages (from-to)	1657-1660
Number of pages	4
Journal	British Journal of Cancer
Volume	102
Issue number	11
DOIs	https://doi.org/10.1038/sj.bjc.6605664
Publication status	Published - 20 Apr 2010

Keywords

adolescent
adult
cervical intraepithelial neoplasia
cervix uteri
DNA, viral
female
humans
middle aged
Pakistan
papillomaviridae
papillomavirus infections
prevalence
uterine cervical neoplasms
vaginal smears
young adult

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.bjc.6605664

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Raza, S. A., Franceschi, S., Pallardy, S., Malik, F. R., Avan, B. I., Zafar, A., Ali, S. H., Pervez, S., Serajuddaula, S., Snijders, P. J. F., van Kemenade, F. J., Meijer, C. J. L. M., Shershah, S., & Clifford, G. M. (2010). Human papillomavirus infection in women with and without cervical cancer in Karachi, Pakistan. British Journal of Cancer, 102(11), 1657-1660. https://doi.org/10.1038/sj.bjc.6605664

Raza, SA, Franceschi, S, Pallardy, S, Malik, FR, Avan, BI, Zafar, A, Ali, SH, Pervez, S, Serajuddaula, S, Snijders, PJF, van Kemenade, FJ, Meijer, CJLM, Shershah, S & Clifford, GM 2010, 'Human papillomavirus infection in women with and without cervical cancer in Karachi, Pakistan', British Journal of Cancer, vol. 102, no. 11, pp. 1657-1660. https://doi.org/10.1038/sj.bjc.6605664

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abstract = "BACKGROUND: No data exist on the population prevalence of, or risk factors for, human papillomavirus (HPV) infection in predominantly Muslim countries in Asia. METHODS: Cervical specimens were obtained from 899 married women aged 15-59 years from the general population of Karachi, Pakistan and from 91 locally diagnosed invasive cervical cancers (ICCs). HPV was detected using a GP5+/6+ PCR-based assay. RESULTS: The prevalence of HPV in the general population was 2.8%, with no evidence of higher HPV prevalence in young women. The positivity of HPV was associated with women's lifetime number of sexual partners, but particularly with the age difference between spouses and other husbands' characteristics, such as extramarital sexual relationships and regular absence from home. The HPV16/18 accounted for 24 and 88% of HPV-positive women in the general population and ICC, respectively. CONCLUSION: Cervical cancer prevention policies should take into account the low HPV prevalence and low acceptability of gynaecological examination in this population.",

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AU - Zafar, A

AU - Ali, S H

AU - Pervez, S

AU - Serajuddaula, S

AU - Snijders, P J F

AU - van Kemenade, F J

AU - Meijer, C J L M

AU - Shershah, S

AU - Clifford, G M

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AB - BACKGROUND: No data exist on the population prevalence of, or risk factors for, human papillomavirus (HPV) infection in predominantly Muslim countries in Asia. METHODS: Cervical specimens were obtained from 899 married women aged 15-59 years from the general population of Karachi, Pakistan and from 91 locally diagnosed invasive cervical cancers (ICCs). HPV was detected using a GP5+/6+ PCR-based assay. RESULTS: The prevalence of HPV in the general population was 2.8%, with no evidence of higher HPV prevalence in young women. The positivity of HPV was associated with women's lifetime number of sexual partners, but particularly with the age difference between spouses and other husbands' characteristics, such as extramarital sexual relationships and regular absence from home. The HPV16/18 accounted for 24 and 88% of HPV-positive women in the general population and ICC, respectively. CONCLUSION: Cervical cancer prevention policies should take into account the low HPV prevalence and low acceptability of gynaecological examination in this population.

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KW - middle aged

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KW - papillomaviridae

KW - papillomavirus infections

KW - prevalence

KW - uterine cervical neoplasms

KW - vaginal smears

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EP - 1660

JO - British Journal of Cancer

JF - British Journal of Cancer

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ER -

Human papillomavirus infection in women with and without cervical cancer in Karachi, Pakistan

Abstract

Keywords

UN SDGs

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