Abstract
Human recombinant tumor necrosis factor α (rTNFα) and rainbow trout macrophage activating factor (postulated γ-interferon (γ-IFN) analogue) synergised to elevate the respiratory burst activity of trout macrophages. This elevated response may parallel phenomena described in mammals where TNFα and γ-IFN commonly synergise. Human rTNFα also synergised with mitogenic stimuli to heighten proliferation responses of trout head kidney leucocytes. These data are indicative of a conserved TNFα receptor on trout leucocytes (and possibly the TNFα molecule itself) and support the notion of an interactive cytokine network regulating immune responses in fish.
Original language | English |
---|---|
Pages (from-to) | 73-84 |
Number of pages | 12 |
Journal | Veterinary Immunology and Immunopathology |
Volume | 40 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 1994 |