Human tumor necrosis factor α influences rainbow trout Oncorhynchus mykiss leucocyte responses

Laura J. Hardie*, Leslie H. Chappell, Christopher J. Secombes

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

80 Citations (Scopus)


Human recombinant tumor necrosis factor α (rTNFα) and rainbow trout macrophage activating factor (postulated γ-interferon (γ-IFN) analogue) synergised to elevate the respiratory burst activity of trout macrophages. This elevated response may parallel phenomena described in mammals where TNFα and γ-IFN commonly synergise. Human rTNFα also synergised with mitogenic stimuli to heighten proliferation responses of trout head kidney leucocytes. These data are indicative of a conserved TNFα receptor on trout leucocytes (and possibly the TNFα molecule itself) and support the notion of an interactive cytokine network regulating immune responses in fish.

Original languageEnglish
Pages (from-to)73-84
Number of pages12
JournalVeterinary Immunology and Immunopathology
Issue number1
Publication statusPublished - Jan 1994


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