Human tumor necrosis factor α influences rainbow trout Oncorhynchus mykiss leucocyte responses

Laura J. Hardie*, Leslie H. Chappell, Christopher J. Secombes

*Corresponding author for this work

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Human recombinant tumor necrosis factor α (rTNFα) and rainbow trout macrophage activating factor (postulated γ-interferon (γ-IFN) analogue) synergised to elevate the respiratory burst activity of trout macrophages. This elevated response may parallel phenomena described in mammals where TNFα and γ-IFN commonly synergise. Human rTNFα also synergised with mitogenic stimuli to heighten proliferation responses of trout head kidney leucocytes. These data are indicative of a conserved TNFα receptor on trout leucocytes (and possibly the TNFα molecule itself) and support the notion of an interactive cytokine network regulating immune responses in fish.

Original languageEnglish
Pages (from-to)73-84
Number of pages12
JournalVeterinary Immunology and Immunopathology
Volume40
Issue number1
DOIs
Publication statusPublished - Jan 1994

Fingerprint

Trout
tumor necrosis factors
Oncorhynchus mykiss
trout
leukocytes
Leukocytes
macrophages
Macrophage-Activating Factors
Head Kidney
Respiratory Burst
Tumor Necrosis Factor Receptors
interferons
Interferons
Mammals
Fishes
cytokines
Macrophages
kidneys
immune response
mammals

ASJC Scopus subject areas

  • Immunology
  • veterinary(all)

Cite this

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