Hydration, Arginine Vasopressin, and Glucoregulatory Health in Humans

A Critical Perspective

Harriet A Carroll (Corresponding Author), Lewis J James (Corresponding Author)

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Glucoregulatory diseases, such as type 2 diabetes are currently a key public health priority. Public health messages have started to include the addition of water in their dietary guidelines. Such guidelines however are not based on causal evidence pertaining to the health effects of increased water intake, but rather more heavily based upon non-causal or mechanistic data. One line of thinking linking fluid intake and health is that hypohydration induces elevated blood concentrations of arginine vasopressin (AVP). Research in the 1970s and 1980s implicated AVP in glucoregulation, supported by observational evidence. This important area of research subsequently appeared to stop until the 21st century during which interest in hypertonic saline infusion studies, animal AVP receptor knockout models, dietary and genetic associations, and human interventions manipulating hydration status have resurged. This narrative review briefly describes and critically evaluates the usefulness of the current AVP-glucoregulatory research. We offer suggestions on how to test the independent glucoregulatory effects of body water changes compared to elevated circulating AVP concentrations, such as investigating hydration manipulations using 3,4-Methylenedioxymethamphetamine. Whilst much research is still needed before making firm conclusions, the current evidence suggests that although AVP may be partially implicated in glucoregulation, more ecologically valid models using human participants suggests this effect might be independent of the hydration status. The key implication of this hypothesis if confirmed in future research is that manipulating the hydration status to reduce circulating AVP concentrations may not be an effective method to improve glucoregulatory health.

Original languageEnglish
Article number1201
JournalNutrients
Volume11
Issue number6
DOIs
Publication statusPublished - 28 May 2019

Fingerprint

arginine vasopressin
Arginine Vasopressin
human health
Health
glucoregulation
Research
Public Health
public health
N-Methyl-3,4-methylenedioxyamphetamine
Health Priorities
Vasopressin Receptors
Nutrition Policy
Body Water
Genetic Models
Medical Genetics
Dietary Guidelines
Type 2 Diabetes Mellitus
Drinking
noninsulin-dependent diabetes mellitus
body water

Keywords

  • vasopressin
  • copeptin
  • hydration
  • health
  • metabolism
  • glycaemia
  • type 2 diabetes
  • diabetes insipidus
  • syndrome of inappropriate anti-diuretic secretion
  • MDMA
  • Type 2 diabetes
  • Hydration
  • Health
  • Diabetes insipidus
  • Metabolism
  • Vasopressin
  • Copeptin
  • Glycaemia
  • Syndrome of inappropriate anti-diuretic secretion
  • THIRST
  • METABOLISM
  • GLUCOSE
  • PLAIN-WATER-INTAKE
  • PLASMA VASOPRESSIN
  • RISK
  • CELLULAR HYDRATION
  • MDMA ECSTASY
  • COPEPTIN
  • SECRETION

Cite this

Hydration, Arginine Vasopressin, and Glucoregulatory Health in Humans : A Critical Perspective. / Carroll, Harriet A (Corresponding Author); James, Lewis J (Corresponding Author).

In: Nutrients, Vol. 11, No. 6, 1201, 28.05.2019.

Research output: Contribution to journalReview article

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abstract = "Glucoregulatory diseases, such as type 2 diabetes are currently a key public health priority. Public health messages have started to include the addition of water in their dietary guidelines. Such guidelines however are not based on causal evidence pertaining to the health effects of increased water intake, but rather more heavily based upon non-causal or mechanistic data. One line of thinking linking fluid intake and health is that hypohydration induces elevated blood concentrations of arginine vasopressin (AVP). Research in the 1970s and 1980s implicated AVP in glucoregulation, supported by observational evidence. This important area of research subsequently appeared to stop until the 21st century during which interest in hypertonic saline infusion studies, animal AVP receptor knockout models, dietary and genetic associations, and human interventions manipulating hydration status have resurged. This narrative review briefly describes and critically evaluates the usefulness of the current AVP-glucoregulatory research. We offer suggestions on how to test the independent glucoregulatory effects of body water changes compared to elevated circulating AVP concentrations, such as investigating hydration manipulations using 3,4-Methylenedioxymethamphetamine. Whilst much research is still needed before making firm conclusions, the current evidence suggests that although AVP may be partially implicated in glucoregulation, more ecologically valid models using human participants suggests this effect might be independent of the hydration status. The key implication of this hypothesis if confirmed in future research is that manipulating the hydration status to reduce circulating AVP concentrations may not be an effective method to improve glucoregulatory health.",
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