@inproceedings{bb51dec6b4c548479b623c9748a128ee,
title = "Hydrodynamic stretching for prostate cancer detection",
abstract = "Advances in diagnostic technologies enabled scientists to link a large number of diseases with structural changes of the intracellular organisation. This intrinsic biophysical characteristic opened up the possibility to perform clinical assessments based on the measurement of single-cell mechanical properties. In this work, we combine microfluidics, high speed imaging and computational automatic tracking to measure the single-cell deformability of large samples of prostate cancer cells at a rate of ∼ 104cells/s. Such a high throughput accounts for the inherent heterogeneity of biological samples and enabled us to extract statistically meaningful signatures from each cell population. In addition, using our technique we investigate the effect of Latrunculin A to the cellular stiffness.",
keywords = "Automated Tracking, Cell Mechanics, High Speed Imaging, High Throughput Diagnosis, Microfluidics, Prostate Cancer",
author = "Yuri Belotti and Michael Conneely and Scott Palmer and Tianjun Huang and Paul Campbell and Stephen McKenna and Ghulam Nabi and David McGloin",
note = "Publisher Copyright: {\textcopyright} 2015 SPIE.; Bio-MEMS and Medical Microdevices II Conference ; Conference date: 05-05-2015 Through 06-05-2015",
year = "2015",
doi = "10.1117/12.2179201",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "{van den Driesche}, Sander",
booktitle = "Bio-MEMS and Medical Microdevices II",
}
