Hypertensive disorders of pregnancy (HDP) and the risk of common cancers in women: Evidence from the European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population-based study.

Zahra  Pasdar; David Gamble; Phyo Kyaw Myint; Robert N. Luben; Nicholas J. Wareham; Kay Tee Khaw; Sohinee Bhattacharya

doi:10.3390/cancers12113100

Hypertensive disorders of pregnancy (HDP) and the risk of common cancers in women: Evidence from the European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population-based study.

Zahra Pasdar, David Gamble, Phyo Kyaw Myint^* (Corresponding Author), Robert N. Luben, Nicholas J. Wareham, Kay Tee Khaw, Sohinee Bhattacharya

^*Corresponding author for this work

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Abstract

urpose: The purpose was to determine the association between HDP and cancer in a UK cohort. Methods: Between 1993 and 1997, participants from the EPIC-Norfolk cohort attended baseline health-checks and completed questionnaires, where a history of HDP was collected. Incident cancer cases were identified through NHS record linkage until March 2016. Univariable and multivariable logistic regression analyses were employed to determine the association between HDP and odds of cancer, with adjustment for potential confounders including co-morbidities, sociodemographic, lifestyle and reproductive factors. Results: 13,562 women were included after excluding prevalent cancer cases and women with no pregnancies. 2919 (21.5%) reported HDP and 2615 incident cancers occurred during mean follow up of 19 years. Median age (IQR) at baseline for incident cancer was 60.8 (±14.8) years. Among incident cancer cases, 578 (22.1%) had HDP. In multivariable analyses, HDP had odds ratio (OR) 1.06; 95% CI 0.95–1.18 for incident cancer. The ORs (95% CIs) for common site-specific cancers including breast, colorectal, lung, ovarian and endometrial cancers were 1.06 (0.88–1.28), 1.15 (0.92–1.45), 0.96 (0.68–1.35), 1.30 (0.93–1.83) and 1.16 (0.80–1.67). Conclusion: We found no association between HDP and cancer risk. Further studies are required to confirm and account for any underlying genetic factors involved in pregnancy-related exposures and cancer risk.

Original language	English
Article number	3100
Number of pages	11
Journal	Cancers
Volume	12
Issue number	11
DOIs	https://doi.org/10.3390/cancers12113100
Publication status	Published - 23 Oct 2020

Bibliographical note

Funding: EPIC-Norfolk study was supported by grants from the Cancer Research UK (CRUK 14136) and Medical Research Council UK (MRC: G1000143). ZP received Aberdeen Summer Research Scholarship funded by the CRANES (Cancer Research in North East Scotland) through the University of Aberdeen Development Trust.
Funders have no role in study design and interpretation of the results.
Acknowledgments: We gratefully acknowledge the participating GP practices and the participants of the EPIC-Norfolk and staff of EPIC-Norfolk. We thank the EPIC-Norfolk Funders, MRC (MRC: G1000143) and CRUK (CRUK 14136) and the University of Aberdeen Development Trust CRANE funding for their future leaders award.
Funders have no role in study design and interpretation of the results.

Keywords

hypertension during pregnancy
Pregnancy complications
cancer
Hypertension during pregnancy
Cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Pasdar, Z., Gamble, D., Myint, P. K., Luben, R. N., Wareham, N. J., Khaw, K. T., & Bhattacharya, S. (2020). Hypertensive disorders of pregnancy (HDP) and the risk of common cancers in women: Evidence from the European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population-based study. Cancers, 12(11), Article 3100. https://doi.org/10.3390/cancers12113100

Hypertensive disorders of pregnancy (HDP) and the risk of common cancers in women: Evidence from the European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population-based study. / Pasdar, Zahra ; Gamble, David; Myint, Phyo Kyaw (Corresponding Author) et al.
In: Cancers, Vol. 12, No. 11, 3100, 23.10.2020.

Research output: Contribution to journal › Article › peer-review

@article{6b4c5dc61efa4000b74817cd196db390,

title = "Hypertensive disorders of pregnancy (HDP) and the risk of common cancers in women: Evidence from the European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population-based study.",

abstract = "urpose: The purpose was to determine the association between HDP and cancer in a UK cohort. Methods: Between 1993 and 1997, participants from the EPIC-Norfolk cohort attended baseline health-checks and completed questionnaires, where a history of HDP was collected. Incident cancer cases were identified through NHS record linkage until March 2016. Univariable and multivariable logistic regression analyses were employed to determine the association between HDP and odds of cancer, with adjustment for potential confounders including co-morbidities, sociodemographic, lifestyle and reproductive factors. Results: 13,562 women were included after excluding prevalent cancer cases and women with no pregnancies. 2919 (21.5%) reported HDP and 2615 incident cancers occurred during mean follow up of 19 years. Median age (IQR) at baseline for incident cancer was 60.8 (±14.8) years. Among incident cancer cases, 578 (22.1%) had HDP. In multivariable analyses, HDP had odds ratio (OR) 1.06; 95% CI 0.95–1.18 for incident cancer. The ORs (95% CIs) for common site-specific cancers including breast, colorectal, lung, ovarian and endometrial cancers were 1.06 (0.88–1.28), 1.15 (0.92–1.45), 0.96 (0.68–1.35), 1.30 (0.93–1.83) and 1.16 (0.80–1.67). Conclusion: We found no association between HDP and cancer risk. Further studies are required to confirm and account for any underlying genetic factors involved in pregnancy-related exposures and cancer risk.",

keywords = "hypertension during pregnancy, Pregnancy complications, cancer, Hypertension during pregnancy, Cancer",

author = "Zahra Pasdar and David Gamble and Myint, {Phyo Kyaw} and Luben, {Robert N.} and Wareham, {Nicholas J.} and Khaw, {Kay Tee} and Sohinee Bhattacharya",

note = "Funding: EPIC-Norfolk study was supported by grants from the Cancer Research UK (CRUK 14136) and Medical Research Council UK (MRC: G1000143). ZP received Aberdeen Summer Research Scholarship funded by the CRANES (Cancer Research in North East Scotland) through the University of Aberdeen Development Trust. Funders have no role in study design and interpretation of the results. Acknowledgments: We gratefully acknowledge the participating GP practices and the participants of the EPIC-Norfolk and staff of EPIC-Norfolk. We thank the EPIC-Norfolk Funders, MRC (MRC: G1000143) and CRUK (CRUK 14136) and the University of Aberdeen Development Trust CRANE funding for their future leaders award. Funders have no role in study design and interpretation of the results. ",

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doi = "10.3390/cancers12113100",

language = "English",

volume = "12",

journal = "Cancers",

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number = "11",

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T1 - Hypertensive disorders of pregnancy (HDP) and the risk of common cancers in women

T2 - Evidence from the European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population-based study.

AU - Pasdar, Zahra

AU - Gamble, David

AU - Myint, Phyo Kyaw

AU - Luben, Robert N.

AU - Wareham, Nicholas J.

AU - Khaw, Kay Tee

AU - Bhattacharya, Sohinee

N1 - Funding: EPIC-Norfolk study was supported by grants from the Cancer Research UK (CRUK 14136) and Medical Research Council UK (MRC: G1000143). ZP received Aberdeen Summer Research Scholarship funded by the CRANES (Cancer Research in North East Scotland) through the University of Aberdeen Development Trust. Funders have no role in study design and interpretation of the results. Acknowledgments: We gratefully acknowledge the participating GP practices and the participants of the EPIC-Norfolk and staff of EPIC-Norfolk. We thank the EPIC-Norfolk Funders, MRC (MRC: G1000143) and CRUK (CRUK 14136) and the University of Aberdeen Development Trust CRANE funding for their future leaders award. Funders have no role in study design and interpretation of the results.

PY - 2020/10/23

Y1 - 2020/10/23

N2 - urpose: The purpose was to determine the association between HDP and cancer in a UK cohort. Methods: Between 1993 and 1997, participants from the EPIC-Norfolk cohort attended baseline health-checks and completed questionnaires, where a history of HDP was collected. Incident cancer cases were identified through NHS record linkage until March 2016. Univariable and multivariable logistic regression analyses were employed to determine the association between HDP and odds of cancer, with adjustment for potential confounders including co-morbidities, sociodemographic, lifestyle and reproductive factors. Results: 13,562 women were included after excluding prevalent cancer cases and women with no pregnancies. 2919 (21.5%) reported HDP and 2615 incident cancers occurred during mean follow up of 19 years. Median age (IQR) at baseline for incident cancer was 60.8 (±14.8) years. Among incident cancer cases, 578 (22.1%) had HDP. In multivariable analyses, HDP had odds ratio (OR) 1.06; 95% CI 0.95–1.18 for incident cancer. The ORs (95% CIs) for common site-specific cancers including breast, colorectal, lung, ovarian and endometrial cancers were 1.06 (0.88–1.28), 1.15 (0.92–1.45), 0.96 (0.68–1.35), 1.30 (0.93–1.83) and 1.16 (0.80–1.67). Conclusion: We found no association between HDP and cancer risk. Further studies are required to confirm and account for any underlying genetic factors involved in pregnancy-related exposures and cancer risk.

AB - urpose: The purpose was to determine the association between HDP and cancer in a UK cohort. Methods: Between 1993 and 1997, participants from the EPIC-Norfolk cohort attended baseline health-checks and completed questionnaires, where a history of HDP was collected. Incident cancer cases were identified through NHS record linkage until March 2016. Univariable and multivariable logistic regression analyses were employed to determine the association between HDP and odds of cancer, with adjustment for potential confounders including co-morbidities, sociodemographic, lifestyle and reproductive factors. Results: 13,562 women were included after excluding prevalent cancer cases and women with no pregnancies. 2919 (21.5%) reported HDP and 2615 incident cancers occurred during mean follow up of 19 years. Median age (IQR) at baseline for incident cancer was 60.8 (±14.8) years. Among incident cancer cases, 578 (22.1%) had HDP. In multivariable analyses, HDP had odds ratio (OR) 1.06; 95% CI 0.95–1.18 for incident cancer. The ORs (95% CIs) for common site-specific cancers including breast, colorectal, lung, ovarian and endometrial cancers were 1.06 (0.88–1.28), 1.15 (0.92–1.45), 0.96 (0.68–1.35), 1.30 (0.93–1.83) and 1.16 (0.80–1.67). Conclusion: We found no association between HDP and cancer risk. Further studies are required to confirm and account for any underlying genetic factors involved in pregnancy-related exposures and cancer risk.

KW - hypertension during pregnancy

KW - Pregnancy complications

KW - cancer

KW - Hypertension during pregnancy

KW - Cancer

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Hypertensive disorders of pregnancy (HDP) and the risk of common cancers in women: Evidence from the European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population-based study.

Abstract

Bibliographical note

Keywords

UN SDGs

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