Hyperzincemia with systemic inflammation: a heritable disorder of calprotectin metabolism with rheumatic manifestations?

Y. Saito, K. Saito, Y. Hirano, K. Ikeya, H. Suzuki, K. Shishikura, S. Manno, Y. Takakuwa, K. Nakagawa, A. Iwasa, S. Fujikawa, M. Moriya, N. Mizoguchi, Barbara Elaine Golden, M. Osawa

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24 Citations (Scopus)

Abstract

A boy had infantile-onset systemic inflammation, growth failure, hepatosplenomegaly, anemia, leukocytopenia, progressive muscular dystrophy, and hypercalprotectinemia, resulting in marked hyperzincemia. His mother had a history of chronic arthritis since childhood and also showed hypercalprotectinemia/hyperzincemia. We postulate an inherent defect in calprotectin metabolism.

Original languageEnglish
Pages (from-to)267-269
Number of pages2
JournalJournal of Paediatrics
Volume140
Issue number2
DOIs
Publication statusPublished - 2002

Keywords

  • ZINC DEPLETION
  • ARTHRITIS
  • PLASMA

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