Hyperzincemia with systemic inflammation: a heritable disorder of calprotectin metabolism with rheumatic manifestations?

Y. Saito, K. Saito, Y. Hirano, K. Ikeya, H. Suzuki, K. Shishikura, S. Manno, Y. Takakuwa, K. Nakagawa, A. Iwasa, S. Fujikawa, M. Moriya, N. Mizoguchi, Barbara Elaine Golden, M. Osawa

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    Abstract

    A boy had infantile-onset systemic inflammation, growth failure, hepatosplenomegaly, anemia, leukocytopenia, progressive muscular dystrophy, and hypercalprotectinemia, resulting in marked hyperzincemia. His mother had a history of chronic arthritis since childhood and also showed hypercalprotectinemia/hyperzincemia. We postulate an inherent defect in calprotectin metabolism.

    Original languageEnglish
    Pages (from-to)267-269
    Number of pages2
    JournalJournal of Paediatrics
    Volume140
    Issue number2
    DOIs
    Publication statusPublished - 2002

    Keywords

    • ZINC DEPLETION
    • ARTHRITIS
    • PLASMA

    Cite this

    Saito, Y., Saito, K., Hirano, Y., Ikeya, K., Suzuki, H., Shishikura, K., Manno, S., Takakuwa, Y., Nakagawa, K., Iwasa, A., Fujikawa, S., Moriya, M., Mizoguchi, N., Golden, B. E., & Osawa, M. (2002). Hyperzincemia with systemic inflammation: a heritable disorder of calprotectin metabolism with rheumatic manifestations? Journal of Paediatrics, 140(2), 267-269. https://doi.org/10.1067/mpd.2002.121699