Hyphenated LC-ICP-MS/ESI-MS identification of halogenated metabolites in South African marine ascidian extracts

Candice L. Bromley, Andrea Raab, Shirley Parker-Nance, Denzil R. Beukes, Marcel Jaspars, Michael T. Davies-Coleman*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)


Extracts of 13 species of marine ascidian collected in Algoa Bay were analyzed by LC-ICP-MS/ESI-MS. This technique allows parallel analysis of the molecular species and the presence of certain elements. The LC-ICP-MS/ESI-MS technique was used to target iodinated metabolites in this study. Three ascidian species afforded the known 3,5-diiodo-4-methoxyphenethylamine (12), which was confirmedby the isolation of this metabolite fromAplidium monile.MS also suggested the presence of theknown 3,5-dibromo-4-methoxyphenethylamine (10) and the new 3-bromo-5-iodo-4-methoxyphenethylamine (11) in the A. monile extract. The presence of the known 3,5-dibromotetramethyltyrosine (21) and the new 3-iodotetramethyltyrosine (23) in extracts of an unidentified Didemnum species was similarly proposed from MS evidence. This is the first report of the occurrence of iodinated metabolites in South African marine invertebrates.

Original languageEnglish
Pages (from-to)111-117
Number of pages7
JournalSouth African Journal of Chemistry
Issue number1
Publication statusPublished - 31 Dec 2018



  • Ascidian
  • Iodinated tyramine
  • Iodinated tyrosine
  • Marine

ASJC Scopus subject areas

  • Chemistry(all)

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