Hyposplenism and gastrointestinal diseases: significance and mechanisms

Abhinav Mathur; Mairi H McLean; Huan Cao; Mark A Vickers

doi:10.1159/000517338

Hyposplenism and gastrointestinal diseases: significance and mechanisms

Abhinav Mathur^* (Corresponding Author), Mairi H McLean, Huan Cao, Mark A Vickers

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

Abstract

Background: Functional hyposplenism is a recognized complication of several gastroenterological disorders, including coeliac and inflammatory bowel diseases, and is believed to contribute to the increased infection risk seen in these disorders. Summary: The mechanisms of hyposplenism are poorly understood. In this article, we review possible mechanisms underlying development of functional hyposplenism and discuss implications for its management. Key Messages: Identifying functional hyposplenism is important, as it may permit earlier recognition and treatment of serious infections through patient education and vaccination.

Original language	English
Pages (from-to)	290–298
Number of pages	9
Journal	Digestive Diseases
Volume	40
Early online date	31 May 2021
DOIs	https://doi.org/10.1159/000517338
Publication status	Published - May 2022

Keywords

hyposplenism
spleen
coeliac disease
inflammatory bowel disease

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000517338Licence: CC BY

Mathur_etal_DD_Small_Large_Bowel_VOR
This article is licensed under the Creative Commons Attribution 4.0 International License (CC BY) (http://www.karger.com/Services/ OpenAccessLicense). Usage, derivative works and distribution are permitted provided that proper credit is given to the author and the original publisher. https://creativecommons.org/licenses/by/4.0/
Final published version, 553 KBLicence: CC BY

Cite this

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title = "Hyposplenism and gastrointestinal diseases: significance and mechanisms",

abstract = "Background: Functional hyposplenism is a recognized complication of several gastroenterological disorders, including coeliac and inflammatory bowel diseases, and is believed to contribute to the increased infection risk seen in these disorders. Summary: The mechanisms of hyposplenism are poorly understood. In this article, we review possible mechanisms underlying development of functional hyposplenism and discuss implications for its management. Key Messages: Identifying functional hyposplenism is important, as it may permit earlier recognition and treatment of serious infections through patient education and vaccination.",

keywords = "hyposplenism, spleen, coeliac disease, inflammatory bowel disease",

author = "Abhinav Mathur and McLean, {Mairi H} and Huan Cao and Vickers, {Mark A}",

note = "Open Access via the Karger Agreement This work was funded in part by Wellcome Trust Grant number 0934847/Z/10/Z. ",

year = "2022",

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doi = "10.1159/000517338",

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journal = "Journal of Digestive Diseases",

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T1 - Hyposplenism and gastrointestinal diseases

T2 - significance and mechanisms

AU - Mathur, Abhinav

AU - McLean, Mairi H

AU - Cao, Huan

AU - Vickers, Mark A

N1 - Open Access via the Karger Agreement This work was funded in part by Wellcome Trust Grant number 0934847/Z/10/Z.

PY - 2022/5

Y1 - 2022/5

N2 - Background: Functional hyposplenism is a recognized complication of several gastroenterological disorders, including coeliac and inflammatory bowel diseases, and is believed to contribute to the increased infection risk seen in these disorders. Summary: The mechanisms of hyposplenism are poorly understood. In this article, we review possible mechanisms underlying development of functional hyposplenism and discuss implications for its management. Key Messages: Identifying functional hyposplenism is important, as it may permit earlier recognition and treatment of serious infections through patient education and vaccination.

AB - Background: Functional hyposplenism is a recognized complication of several gastroenterological disorders, including coeliac and inflammatory bowel diseases, and is believed to contribute to the increased infection risk seen in these disorders. Summary: The mechanisms of hyposplenism are poorly understood. In this article, we review possible mechanisms underlying development of functional hyposplenism and discuss implications for its management. Key Messages: Identifying functional hyposplenism is important, as it may permit earlier recognition and treatment of serious infections through patient education and vaccination.

KW - hyposplenism

KW - spleen

KW - coeliac disease

KW - inflammatory bowel disease

U2 - 10.1159/000517338

DO - 10.1159/000517338

M3 - Review article

C2 - 34034254

VL - 40

SP - 290

EP - 298

JO - Journal of Digestive Diseases

JF - Journal of Digestive Diseases

SN - 1751-2972

ER -

Hyposplenism and gastrointestinal diseases: significance and mechanisms

Abstract

Keywords

UN SDGs

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