Hypothalamic orexigenic peptides are overexpressed in young Long-Evans rats after early life exposure to fat-rich diets

Bernard Beck, Rouba Kozak, Kim M Moar, Julian Mercer

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Nutritional factors have a critical influence during prenatal life on the development and regulation of networks involved in body weight and feeding regulation. To establish the influence of the macronutrient type on feeding regulatory mechanisms and more particularly on stimulatory pathways (galanin and orexins), we fed female rats on either a high-carbohydrate (HC), a high-fat (HF), or a well-balanced control diet during gestation and lactation, and measured peptide expression in the hypothalamus and important hormones (leptin, insulin) in their pups at weaning. HF weanlings were 30% lighter than control and HC pups (P
Original languageEnglish
Pages (from-to)452-458
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume342
Issue number2
DOIs
Publication statusPublished - 7 Apr 2006

Keywords

  • Aging
  • Animals
  • Body Weight
  • Dietary Fats
  • Female
  • Galanin
  • Hypothalamus
  • Intracellular Signaling Peptides and Proteins
  • Neuropeptides
  • Neurotensin
  • Peptide Hormones
  • Peptides
  • RNA, Messenger
  • Rats
  • Rats, Long-Evans

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