Abstract
Nutritional factors have a critical influence during prenatal life on the development and regulation of networks involved in body weight and feeding regulation. To establish the influence of the macronutrient type on feeding regulatory mechanisms and more particularly on stimulatory pathways (galanin and orexins), we fed female rats on either a high-carbohydrate (HC), a high-fat (HF), or a well-balanced control diet during gestation and lactation, and measured peptide expression in the hypothalamus and important hormones (leptin, insulin) in their pups at weaning. HF weanlings were 30% lighter than control and HC pups (P
Original language | English |
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Pages (from-to) | 452-458 |
Number of pages | 7 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 342 |
Issue number | 2 |
DOIs | |
Publication status | Published - 7 Apr 2006 |
Keywords
- Aging
- Animals
- Body Weight
- Dietary Fats
- Female
- Galanin
- Hypothalamus
- Intracellular Signaling Peptides and Proteins
- Neuropeptides
- Neurotensin
- Peptide Hormones
- Peptides
- RNA, Messenger
- Rats
- Rats, Long-Evans